Title:
NOVEL PEPTIDE DIMERS AS AGONISTS OF THE ERYTHROPOIETIN (EPO) RECEPTOR, AND ASSOCIATED METHODS OF SYNTHESIS AND USE
Document Type and Number:
WIPO Patent Application WO2001038342
Kind Code:
A3
Abstract:
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R1 and a second peptide chain R2, wherein R1 and R2 may be the same or different, and are linked through a linking moiety. R1 is approximately 10 to 40 amino acid residues in length and comprises the sequence X3X4X5GPX6TX7X8X9 (SEQ ID NO: 1) wherein X3 is C or Hoc, X4 is R, H, L or W, X5 is M, F, I or nor-leucine (J), X6 is any one of the 20 genetically coded L-amino acids or J, X7 is W, 1-naphthylalanine (B) or 2-naphthylalanine (U), X8 is D, E, I, L or V, and X9 is C or Hoc. Similarly, R2 comprises the sequence X'3X'4X'5GPX'6TX'7X'8X'9 (SEQ ID NO: 2) wherein X'3 is C or Hoc, X'4 is R, H, L or W, X'5 is M, F, I or J, x'6 is any one of the 20 genetically coded L-amino acids or J, X'7 is W, B or U, X'8 is D, E, I, L or V and X'9 is C or Hoc. Methods for synthesizing the compounds are provided as well, as are pharmaceutical compositions and methods of use.
Inventors:
BALU PALANI (US)
Application Number:
PCT/US2000/032224
Publication Date:
June 15, 2006
Filing Date:
November 24, 2000
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
BALU PALANI (US)
BALU PALANI (US)
International Classes:
C07K1/107; C07K14/505; A61K38/00; (IPC1-7): C07K1/00; C07K14/505; C07K17/00
Foreign References:
| US5061786A | 1991-10-29 |
Other References:
See also references of EP 1578768A4
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