Title:
NOVEL PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2023/068287
Kind Code:
A1
Abstract:
Provided is a novel pharmaceutical as a therapeutic medication for COVID-19. The present invention relates to a pharmaceutical obtained by combining ivermectin and molnupiravir, a therapeutic medication for prevention and/or treatment of SARS-CoV-2 infection obtained by combining ivermectin and molnupiravir, and a therapeutic medication for prevention and/or treatment of COVID-19 obtained by combining ivermectin and molnupiravir.
Inventors:
SHIRAISHI KOUICHI (JP)
OKUMURA MUTSUO (JP)
OKUMURA MUTSUO (JP)
Application Number:
PCT/JP2022/038872
Publication Date:
April 27, 2023
Filing Date:
October 19, 2022
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
A61K31/7068; A61K31/7048; A61P31/12; A61P43/00
Domestic Patent References:
| WO2019113462A1 | 2019-06-13 |
Other References:
AJAYI AAL: "Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin", AUSTIN J PHARMACOL THER, vol. 9, no. 5, 1 August 2021 (2021-08-01), pages 1149, XP093059006
IMRAN MOHD., KUMAR ARORA MANDEEP, ASDAQ SYED MOHAMMED BASHEERUDDIN, KHAN SHAH ALAM, ALAQEL SALEH I., ALSHAMMARI MOHAMMED KANAN, AL: "Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19", MOLECULES, vol. 26, no. 19, 24 September 2021 (2021-09-24), pages 5795 - 599577945, XP055923049, DOI: 10.3390/molecules26195795
ABD‐ELSALAM SHERIEF, NOOR RASHA A., BADAWI REHAB, KHALAF MAI, ESMAIL ESLAM S., SOLIMAN SHAIMAA, ABD EL GHAFAR MOHAMED S., ELBAHNAS: "Clinical study evaluating the efficacy of ivermectin in COVID‐19 treatment: A randomized controlled study", JOURNAL OF MEDICAL VIROLOGY, JOHN WILEY & SONS, INC., US, vol. 93, no. 10, 1 October 2021 (2021-10-01), US , pages 5833 - 5838, XP093059008, ISSN: 0146-6615, DOI: 10.1002/jmv.27122
COX ROBERT M.; WOLF JOSEF D.; PLEMPER RICHARD K.: "Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets", NATURE MICROBIOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 6, no. 1, 1 January 1900 (1900-01-01), London , pages 11 - 18, XP037319215, DOI: 10.1038/s41564-020-00835-2
ERRECALDE JORGE, LIFSCHITZ ADRIAN, VECCHIOLI GRACIELA, CEBALLOS LAURA, ERRECALDE FRANCISCO, BALLENT MARIANA, MARÍN GUSTAVO, DANIEL: "Safety and Pharmacokinetic Assessments of a Novel Ivermectin Nasal Spray Formulation in a Pig Model", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 110, no. 6, 23 January 2021 (2021-01-23), US , pages 2501 - 2507, XP055963463, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2021.01.017
M. MANSOUR SUZAN; N. SHAMMA REHAB; A. AHMED KAWKAB; A. SABRY NIRMEEN; ESMAT GAMAL; A. MAHMOUD AZZA; MAGED AMR: "Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 99, 23 July 2021 (2021-07-23), NL , XP086760350, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2021.108004
IMRAN MOHD., KUMAR ARORA MANDEEP, ASDAQ SYED MOHAMMED BASHEERUDDIN, KHAN SHAH ALAM, ALAQEL SALEH I., ALSHAMMARI MOHAMMED KANAN, AL: "Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19", MOLECULES, vol. 26, no. 19, 24 September 2021 (2021-09-24), pages 5795 - 599577945, XP055923049, DOI: 10.3390/molecules26195795
ABD‐ELSALAM SHERIEF, NOOR RASHA A., BADAWI REHAB, KHALAF MAI, ESMAIL ESLAM S., SOLIMAN SHAIMAA, ABD EL GHAFAR MOHAMED S., ELBAHNAS: "Clinical study evaluating the efficacy of ivermectin in COVID‐19 treatment: A randomized controlled study", JOURNAL OF MEDICAL VIROLOGY, JOHN WILEY & SONS, INC., US, vol. 93, no. 10, 1 October 2021 (2021-10-01), US , pages 5833 - 5838, XP093059008, ISSN: 0146-6615, DOI: 10.1002/jmv.27122
COX ROBERT M.; WOLF JOSEF D.; PLEMPER RICHARD K.: "Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets", NATURE MICROBIOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 6, no. 1, 1 January 1900 (1900-01-01), London , pages 11 - 18, XP037319215, DOI: 10.1038/s41564-020-00835-2
ERRECALDE JORGE, LIFSCHITZ ADRIAN, VECCHIOLI GRACIELA, CEBALLOS LAURA, ERRECALDE FRANCISCO, BALLENT MARIANA, MARÍN GUSTAVO, DANIEL: "Safety and Pharmacokinetic Assessments of a Novel Ivermectin Nasal Spray Formulation in a Pig Model", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 110, no. 6, 23 January 2021 (2021-01-23), US , pages 2501 - 2507, XP055963463, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2021.01.017
M. MANSOUR SUZAN; N. SHAMMA REHAB; A. AHMED KAWKAB; A. SABRY NIRMEEN; ESMAT GAMAL; A. MAHMOUD AZZA; MAGED AMR: "Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 99, 23 July 2021 (2021-07-23), NL , XP086760350, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2021.108004
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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