Title:
NOVEL PHOTOSENSITIZER
Document Type and Number:
WIPO Patent Application WO/2021/167022
Kind Code:
A1
Abstract:
[Problem] To provide a probe capable of inducing the destruction of actin fiber in a spatiotemporally selective manner, and a method using the same. [Solution] Provided is a compound represented by formula (I) or a salt thereof.
Inventors:
URANO YASUTERU (JP)
UENO TASUKU (JP)
TAKAGI TAKERU (JP)
ASANUMA DAISUKE (JP)
UENO TASUKU (JP)
TAKAGI TAKERU (JP)
ASANUMA DAISUKE (JP)
Application Number:
PCT/JP2021/006211
Publication Date:
August 26, 2021
Filing Date:
February 18, 2021
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07D311/82; A61K31/352; A61K41/00; A61P43/00; C09K3/00
Domestic Patent References:
| WO2014100822A1 | 2014-06-26 |
Other References:
TAKAGI, TAKERU : "The 42nd Annual Meeting of the Molecular Biology Society of Japan; December 3-6, 2019", THE 42ND ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN; DECEMBER 3-6, 2019, 19 November 2019 (2019-11-19), pages 4P-0632, XP009530812, ISSN: 1347-4219
TAKEMOTO KIWAMU, MATSUDA TOMOKI, MCDOUGALL MARK, KLAUBERT DIETER H., HASEGAWA AKIRA, LOS GEORGYI V., WOOD KEITH V., MIYAWAKI ATSUS: "Chromophore-Assisted Light Inactivation of HaloTag Fusion Proteins Labeled with Eosin in Living Cells", ACS CHEMICAL BIOLOGY, vol. 6, no. 5, 20 May 2011 (2011-05-20), pages 401 - 406, XP055850094, ISSN: 1554-8929, DOI: 10.1021/cb100431e
WANG, Y.-L. ; LANSING TAYLOR, D.: "Probing the dynamic equilibrium of actin polymerization by fluorescence energy transfer", CELL, ELSEVIER, AMSTERDAM NL, vol. 27, no. 3, 1 December 1981 (1981-12-01), Amsterdam NL, pages 429 - 436, XP023911808, ISSN: 0092-8674, DOI: 10.1016/0092-8674(81)90384-6
LIU CHAOHONG; MILLER HEATHER; SHARMA SHRUTI; BEAVEN AMY; UPADHYAYA ARPITA; SONG WENXIA: "Analyzing actin dynamics during the activation of the B cell receptor in live B cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 427, no. 1, 1 January 1900 (1900-01-01), Amsterdam NL, pages 202 - 206, XP028948563, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2012.09.046
TAKAGI, TAKERU, ET AL.: "Novel F-actin binding molecule as a plat form for fluorescent probe and functional probes", 138TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2018 (2018-03-05), XP055850092
UENO TASUKU: "Manipulation of Actin Cytoskeleton with Small-Molecular Probes", 2018 RESEARCH-STATUS REPORT OF KAKENHI, 27 December 2019 (2019-12-27), XP055850085, Retrieved from the Internet
TAKAGI TAKERU, UENO TASUKU, IKAWA KEISUKE, ASANUMA DAISUKE, NOMURA YUSUKE, UNO SHIN-NOSUKE, KOMATSU TORU, KAMIYA MAKO, HANAOKA KEN: "Visualization and manipulation of actin cytoskeleton with small-molecular probes", CHEMRXIV, 11 May 2020 (2020-05-11), XP055850075, Retrieved from the Internet DOI: 10.26434/chemrxiv.12272024.v1
TAKEMOTO KIWAMU, MATSUDA TOMOKI, MCDOUGALL MARK, KLAUBERT DIETER H., HASEGAWA AKIRA, LOS GEORGYI V., WOOD KEITH V., MIYAWAKI ATSUS: "Chromophore-Assisted Light Inactivation of HaloTag Fusion Proteins Labeled with Eosin in Living Cells", ACS CHEMICAL BIOLOGY, vol. 6, no. 5, 20 May 2011 (2011-05-20), pages 401 - 406, XP055850094, ISSN: 1554-8929, DOI: 10.1021/cb100431e
WANG, Y.-L. ; LANSING TAYLOR, D.: "Probing the dynamic equilibrium of actin polymerization by fluorescence energy transfer", CELL, ELSEVIER, AMSTERDAM NL, vol. 27, no. 3, 1 December 1981 (1981-12-01), Amsterdam NL, pages 429 - 436, XP023911808, ISSN: 0092-8674, DOI: 10.1016/0092-8674(81)90384-6
LIU CHAOHONG; MILLER HEATHER; SHARMA SHRUTI; BEAVEN AMY; UPADHYAYA ARPITA; SONG WENXIA: "Analyzing actin dynamics during the activation of the B cell receptor in live B cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 427, no. 1, 1 January 1900 (1900-01-01), Amsterdam NL, pages 202 - 206, XP028948563, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2012.09.046
TAKAGI, TAKERU, ET AL.: "Novel F-actin binding molecule as a plat form for fluorescent probe and functional probes", 138TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2018 (2018-03-05), XP055850092
UENO TASUKU: "Manipulation of Actin Cytoskeleton with Small-Molecular Probes", 2018 RESEARCH-STATUS REPORT OF KAKENHI, 27 December 2019 (2019-12-27), XP055850085, Retrieved from the Internet
TAKAGI TAKERU, UENO TASUKU, IKAWA KEISUKE, ASANUMA DAISUKE, NOMURA YUSUKE, UNO SHIN-NOSUKE, KOMATSU TORU, KAMIYA MAKO, HANAOKA KEN: "Visualization and manipulation of actin cytoskeleton with small-molecular probes", CHEMRXIV, 11 May 2020 (2020-05-11), XP055850075, Retrieved from the Internet
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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