Title:
NOVEL PI POLYAMIDE
Document Type and Number:
WIPO Patent Application WO/2014/142092
Kind Code:
A1
Abstract:
Provided is a medicinal agent which is useful for the prevention or treatment of prostate cancer and is safe and stable.
A novel PI polyamide is obtained, which can recognize a nucleotide sequence that occurs in a transcription regulatory domain (an AR responsive domain) in ACSL3 gene and is specific to an Oct1 gene binding sequence capable of regulating the transcriptional activity of AR and can bind to the nucleotide sequence. Thus, also provided are an ACSL3 gene expression inhibitor and a prophylactic and/or therapeutic agent for prostate cancer, each of which contains the PI polyamide as an active ingredient.
Inventors:
OBINATA DAISUKE (JP)
TAKAHASHI SATORU (JP)
FUJIWARA KYOKO (JP)
INOUE SATOSHI (JP)
TAKAYAMA KENICHI (JP)
TAKAHASHI SATORU (JP)
FUJIWARA KYOKO (JP)
INOUE SATOSHI (JP)
TAKAYAMA KENICHI (JP)
Application Number:
PCT/JP2014/056251
Publication Date:
September 18, 2014
Filing Date:
March 11, 2014
Export Citation:
Assignee:
UNIV NIHON (JP)
International Classes:
C07D403/14; A61K31/787; A61P13/08; A61P35/00; C12N15/09
Domestic Patent References:
| WO2009066774A1 | 2009-05-28 |
Foreign References:
| US20090042965A1 | 2009-02-12 | |||
| JP2013234135A | 2013-11-21 | |||
| US20110046070A1 | 2011-02-24 | |||
| JP2012106382A | 2012-06-07 |
Other References:
CHRISTIAN DOSE ET AL.: "Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, 2008, pages 6859 - 6866, XP055290181
NICHOLAS G. NICKOLS ET AL.: "Suppression of Androgen Receptor-mediated Gene Expression by a Sequence-specific DNA-bindig Polyamide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 25, 2007, pages 10418 - 10423, XP055290218
TOMLINS SA ET AL., SCIENCE, vol. 310, 2005, pages 644 - 648
DAISUKE OBINATA ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 130, 2012, pages 1021 - 1028
See also references of EP 2975036A4
NICHOLAS G. NICKOLS ET AL.: "Suppression of Androgen Receptor-mediated Gene Expression by a Sequence-specific DNA-bindig Polyamide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 25, 2007, pages 10418 - 10423, XP055290218
TOMLINS SA ET AL., SCIENCE, vol. 310, 2005, pages 644 - 648
DAISUKE OBINATA ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 130, 2012, pages 1021 - 1028
See also references of EP 2975036A4
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
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