Title:
NOVEL POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2000/050608
Kind Code:
A1
Abstract:
A novel polypeptide having a $g(b)1, 3-galactose transferase activity participating in the synthesis of type 1 sugar chains; a DNA encoding this polypeptide; a recombinant vector containing this DNA; a transformant having this recombinant vector; a process for producing a sugar chain-complex carbohydrate containing the above polypeptide or a type 1 sugar chain by using the above polypeptide or the above transformant; an antibody recognizing the polypeptide; a method for detecting and quantitating the polypeptide by using this antibody; a method for screening a substance relating to the polypeptide; a method for diagnosing and treating digestive cancer by using the DNA or the antibody; and a method for treating digestive cancer by using a substance obtained by the above screening method.
Inventors:
NARIMATSU HISASHI (JP)
ISSHIKI SOICHIRO (JP)
TOGAYACHI AKIRA (JP)
SASAKI KATSUTOSHI (JP)
ISSHIKI SOICHIRO (JP)
TOGAYACHI AKIRA (JP)
SASAKI KATSUTOSHI (JP)
Application Number:
PCT/JP2000/001070
Publication Date:
August 31, 2000
Filing Date:
February 24, 2000
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
NARIMATSU HISASHI (JP)
ISSHIKI SOICHIRO (JP)
TOGAYACHI AKIRA (JP)
SASAKI KATSUTOSHI (JP)
NARIMATSU HISASHI (JP)
ISSHIKI SOICHIRO (JP)
TOGAYACHI AKIRA (JP)
SASAKI KATSUTOSHI (JP)
International Classes:
C12N15/09; A01K67/027; C12N1/21; C12N5/00; C12N5/10; C12N9/10; C12N15/54; C12P19/00; C12P19/04; C12P21/02; C12P21/08; C12Q1/68; G01N33/53; A61K38/00; A61K39/00; C12R1/185; C12R1/91; (IPC1-7): C12N15/54; C12P21/02; C12N9/10; C12N1/21; C12N5/14; C12N5/16; C12Q1/68; C12N15/63; A01K67/027; G01N33/15; G01N33/50; G01N33/574; A01H5/00
Foreign References:
| JPH1156373A | 1999-03-02 | |||
| JPH06181759A | 1994-07-05 |
Other References:
ZHOU, D. ET. AL: "Molecular cloning of a human UDP-galactose: GlcNAc beta 1,3 galactosyltranferase gene encoding an O-linked core3-elongation enzyme.", EUR. J. BIOCHEM, vol. 263, no. 2, July 1999 (1999-07-01), pages 571 - 576, XP002928038
ISSHIKI, S. ET. AL.: "Cloning, expression, and characterization of a novel UDP-galactose: beta-N acetyglucosamine beta 1,3-glactosyltranferase ( beta3Gal.T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom.", J. BIOL. CHEM., vol. 274, no. 18, April 1999 (1999-04-01), pages 12499 - 12507, XP002928039
BARDONI, A. ET. AL: "Differential expression of beta1,3 galatosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa.", FEBS LETTERS, vol. 451, no. 1, May 1999 (1999-05-01), pages 75 - 80, XP002928040
ZHOU. D. ET. AL: "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.", PROC. NATL. ACID. SCI. USA, vol. 96, no. 2, January 1999 (1999-01-01), pages 406 - 411, XP002928041
AMADO. M. ET. AL: "A family of human beta 3-galactosyltranferases.", J. BIOL. CHEM., vol. 273, no. 21, 1998, pages 12770 - 12778, XP002928042
HENNET- T. ET. AL: "Genomic cloning and expression of three murine UDP-galactose : Beta-N-acetylglucosamine beta1,3-galatosyltransferase genes.", J. BIOL. CHEM, vol. 273, no. 1, 1998, pages 58 - 65, XP002928043
See also references of EP 1162269A4
ISSHIKI, S. ET. AL.: "Cloning, expression, and characterization of a novel UDP-galactose: beta-N acetyglucosamine beta 1,3-glactosyltranferase ( beta3Gal.T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom.", J. BIOL. CHEM., vol. 274, no. 18, April 1999 (1999-04-01), pages 12499 - 12507, XP002928039
BARDONI, A. ET. AL: "Differential expression of beta1,3 galatosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa.", FEBS LETTERS, vol. 451, no. 1, May 1999 (1999-05-01), pages 75 - 80, XP002928040
ZHOU. D. ET. AL: "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.", PROC. NATL. ACID. SCI. USA, vol. 96, no. 2, January 1999 (1999-01-01), pages 406 - 411, XP002928041
AMADO. M. ET. AL: "A family of human beta 3-galactosyltranferases.", J. BIOL. CHEM., vol. 273, no. 21, 1998, pages 12770 - 12778, XP002928042
HENNET- T. ET. AL: "Genomic cloning and expression of three murine UDP-galactose : Beta-N-acetylglucosamine beta1,3-galatosyltransferase genes.", J. BIOL. CHEM, vol. 273, no. 1, 1998, pages 58 - 65, XP002928043
See also references of EP 1162269A4
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