Title:
NOVEL PYRROLIDINE COMPOUND AND APPLICATION AS MELANOCORTIN RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2015/182723
Kind Code:
A1
Abstract:
Provided are a novel pyrrolidine compound having melanocorin receptor agonist activity, a pharmacologically acceptable salt thereof, and pharmaceutical applications thereof. The present invention pertains to a pyrrolidine derivative represented by general formula (I) (in the formula, ring A represents a substitutable aryl group or the like; R1 represents a substitutable alkyl group; R2 represents a halogen atom or the like; R3 represents an alkyl group which may be substituted by a substitutable aryl group; and R4 is a hydrogen atom or the like; or R3 and R4 are terminally bonded to one another, and together with the nitrogen atoms bonded thereto, form substitutable nitrogen-containing aliphatic heterocycles which may partially contain double bonds), or a pharmacologically acceptable salt thereof.
Inventors:
YAMAMOTO YASUO (JP)
SATO ATSUSHI (JP)
MOROKUMA KENJI (JP)
SHITAMA HIROAKI (JP)
ADACHI TAKASHI (JP)
MIYASHIRO MASAHIKO (JP)
SATO ATSUSHI (JP)
MOROKUMA KENJI (JP)
SHITAMA HIROAKI (JP)
ADACHI TAKASHI (JP)
MIYASHIRO MASAHIKO (JP)
Application Number:
PCT/JP2015/065469
Publication Date:
December 03, 2015
Filing Date:
May 28, 2015
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
C07D207/16; A61K31/454; A61K31/4545; A61K31/496; A61K31/501; A61K31/506; A61K31/5377; A61P1/04; A61P1/16; A61P7/00; A61P9/00; A61P9/10; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/04; A61P19/06; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D405/14; C07D413/14; C07D417/14; C07D487/04
Domestic Patent References:
| WO2005040109A1 | 2005-05-06 |
Foreign References:
| JP2003519135A | 2003-06-17 | |||
| JP2003519139A | 2003-06-17 | |||
| JP2010512304A | 2010-04-22 | |||
| JP2009543774A | 2009-12-10 |
Other References:
HERPIN, T. F. ET AL.: "Discovery of Tyrosine- Based Potent and Selective Melanocortin-1 Receptor Small-Molecule Agonists with Anti- inflammatory Properties", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 7, 2003, pages 1123 - 1126, XP001182772, ISSN: 0022-2623
TIAN, X. ET AL.: "Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 15, 2006, pages 4745 - 4761, XP055241673, ISSN: 0022-2623
See also references of EP 3150578A4
TIAN, X. ET AL.: "Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 15, 2006, pages 4745 - 4761, XP055241673, ISSN: 0022-2623
See also references of EP 3150578A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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