SUBSTITUTED TROPANE DERIVATIVES

Title:

SUBSTITUTED TROPANE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2015/182724

Kind Code:

A1

Abstract:

　Provided are compounds that are useful as prophylactic or therapeutic agents for various diseases involving T-type calcium channels, such as hypertension, arrhythmia, pain and cancer, said compounds having antagonistic activity against T-type calcium channels, being highly stable in the body, and being low risk in terms of genotoxicity and the like.　The present invention provides compounds represented by general formula (I), and pharmaceutically acceptable salts or solvates thereof. [In general formula (I): R1 represents -NH(C=O)-V-R3, -(C=O)NH-V-R3, or the like; V represents a single bond, methylene, or -C(CH3)2O-; R2 represents an optionally-substitutable C1-6 alkyl group or the like; X represents a hydrogen atom, an oxygen atom, a hydroxyl group, a methyl group or a methylene group; A represents -NR6-, -O-CH2-, or -S-CH2-; n represents the number of methylene chains, and is an integer of 0, 1 or 2; and the dotted line represents a single or double bond].

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Inventors:

MASAKI HIDEKAZU (JP)
IWASAKI YOICHI (JP)
KAGEYAMA MASAYUKI (JP)
UCHINO YUJIRO (JP)

Application Number:

PCT/JP2015/065471

Publication Date:

December 03, 2015

Filing Date:

May 28, 2015

Export Citation:

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Assignee:

TOA EIYO LTD (JP)

International Classes:

C07D451/02; A61K31/439; A61P3/04; A61P9/04; A61P9/06; A61P9/12; A61P13/12; A61P25/04; A61P25/08; A61P25/20; A61P35/00; A61P43/00; C07D519/00

Domestic Patent References:

WO2011148956A1

2011-12-01

Foreign References:

JP2011529884A	2011-12-15
JPH07503463A	1995-04-13
JPH03167184A	1991-07-19

Other References: