Title:
NOVEL SALT OF NICLOSAMIDE, MOLECULAR AGGREGATE THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2024/049167
Kind Code:
A1
Abstract:
The present invention relates to a novel salt of niclosamide or a molecular aggregate containing niclosamide with improved physical properties. More specifically, the present invention relates to a novel salt of niclosamide or a molecular aggregate containing niclosamide, which has significantly better solubility and bioavailability compared to niclosamide, and a pharmaceutical composition containing same.
Inventors:
KIM CHUL HWAN (KR)
KIM KYOUNG HEE (KR)
LEE EUN JOO (KR)
LEE HYE WON (KR)
SHIN SEOK HO (KR)
KIM KYOUNG HEE (KR)
LEE EUN JOO (KR)
LEE HYE WON (KR)
SHIN SEOK HO (KR)
Application Number:
PCT/KR2023/012799
Publication Date:
March 07, 2024
Filing Date:
August 29, 2023
Export Citation:
Assignee:
SCAI THERAPEUTICS CO LTD (KR)
International Classes:
C07C235/56; A61K9/00; A61K9/14; A61K31/167; A61P17/06; A61P31/14
Domestic Patent References:
| WO2021198115A1 | 2021-10-07 | |||
| WO2021040337A1 | 2021-03-04 |
Foreign References:
| CN104857515A | 2015-08-26 | |||
| CN110833623A | 2020-02-25 |
Other References:
FRANCESCA GRIFASI, MICHELE R. CHIEROTTI, KATIA GAGLIOTI, ROBERTO GOBETTO, LUCIA MAINI, DARIO BRAGA, ELENA DICHIARANTE, MARCO CURZI: "Using Salt Cocrystals to Improve the Solubility of Niclosamide", CRYSTAL GROWTH & DESIGN, ASC WASHINGTON DC, US, vol. 15, no. 4, 1 April 2015 (2015-04-01), US , pages 1939 - 1948, XP055244077, ISSN: 1528-7483, DOI: 10.1021/acs.cgd.5b00106
Attorney, Agent or Firm:
KIM, Sung Ho (KR)
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