Title:
NOVEL SYNTHETIC NUCLEIC ACIDS WHOSE SUGAR MOIETIES HAVE S-CONFIGURATION
Document Type and Number:
WIPO Patent Application WO/2004/037842
Kind Code:
A1
Abstract:
Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 is hydrogen, a hydroxyl-protecting group for synthesis of nucleic acids, or the like; R2 is hydrogen, alkyl having 1 to 6 carbon atoms, or an amino-protecting group for synthesis of nucleic acids; and B is optionally substituted purin-9-yl or 2-oxo-1,2-dihydropyrimidin-1-yl.
Inventors:
IMANISHI TAKESHI (JP)
OBIKA SATOSHI (JP)
OBIKA SATOSHI (JP)
Application Number:
PCT/JP2003/013496
Publication Date:
May 06, 2004
Filing Date:
October 22, 2003
Export Citation:
Assignee:
SANKYO CO (JP)
IMANISHI TAKESHI (JP)
OBIKA SATOSHI (JP)
IMANISHI TAKESHI (JP)
OBIKA SATOSHI (JP)
International Classes:
C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H21/00; (IPC1-7): C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H21/00
Domestic Patent References:
| WO2001000641A1 | 2001-01-04 | |||
| WO2001018015A1 | 2001-03-15 |
Foreign References:
| CA2077314A1 | 1993-03-04 |
Other References:
OBIKA, SATOSHI ET AL.: "Synthesis of a novel bridged nucleoside bearing a fused-azetidine ring, 3'-amino-3', 4'-BNA monomer", TETRAHEDRON LETTERS, vol. 44, no. 28, 7 July 2003 (2003-07-07), pages 5267 - 5270, XP004430962
KOJINA, NAOSHI ET AL.: "Synthesis of ribonucleic guanidine: replacement of the negative phosphodiester linkages of RNA with positive guanidinium linkages", TETRAHEDRON, vol. 58, no. 5, 28 January 2002 (2002-01-28), pages 867 - 879, XP004332709
KOJINA, NAOSHI ET AL.: "Synthesis of ribonucleic guanidine: replacement of the negative phosphodiester linkages of RNA with positive guanidinium linkages", TETRAHEDRON, vol. 58, no. 5, 28 January 2002 (2002-01-28), pages 867 - 879, XP004332709
Attorney, Agent or Firm:
Ohno, Akio c/o SANKYO COMPANY (LIMITED 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, JP)
Download PDF: