Title:
STEROID COMPOUNDS COMPRISING SUPEROXIDE DISMUTASE MIMIC GROUPS AND NITRIC OXIDE DONOR GROUPS, AND THEIR USE IN THE PREPARATION OF MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO2004037843
Kind Code:
A3
Abstract:
The present invention relates to multifunctional steroid compounds combining a steroid component with SOD mimic component and optionally also with NO donor component, and to their use in treating and preventing disorders associated with oxidative stress and free radical injury, or disorders in which treatment with steroids is indicated, whereas such combination increases the efficacy of treatment and reduces side effects associated with steroid treatment. The invention further relates to methods and devices for administering the compounds.
Inventors:
HAJ-YEHIA ABDULLAH IBRAHIM (IL)
Application Number:
PCT/IL2003/000878
Publication Date:
June 10, 2004
Filing Date:
October 24, 2003
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
HAJ-YEHIA ABDULLAH IBRAHIM (IL)
HAJ-YEHIA ABDULLAH IBRAHIM (IL)
International Classes:
A61K31/58; A61K45/06; C07J21/00; C07J43/00; (IPC1-7): C07J21/00; C07J43/00; A61K31/58
Domestic Patent References:
| WO2000049993A2 | 2000-08-31 |
Foreign References:
| US5750744A | 1998-05-12 | |||
| US5707984A | 1998-01-13 | |||
| US5985862A | 1999-11-16 | |||
| US3054812A | 1962-09-18 | |||
| US3215713A | 1965-11-02 | |||
| US3014932A | 1961-12-26 |
Other References:
ZE'EV ZARETSKII AND L. KELNER: "Mass Spectrometry of Steroid Systems-XXII", TETRAHEDRON, vol. 31, 1975, pages 85 - 87, XP002275441
KEANA, JOHN F. W. ET AL: "Synthesis of a novel cholesterol nitric oxide spin label. Application to the molecular organisation of human high density lipoprotein", J. AMER. CHEM.SOC, vol. 103, no. 16, 1981, pages 4904 - 4912, XP002275442
DJERBASSI ET AL.: "Reaction of Steroidal Sapogenin Spiroketal with Ethanediol", J. ORG. CHEM., vol. 24, no. 1, 3 February 1959 (1959-02-03), pages 1 - 6, XP002275443
SONDHEIMER F. ET AL.: "Steroids. LXVII. The Decarboxylation of Unsaturated Steroidal Acids. Synthesis of 17-Epitestosterone and 17-methylepitestosterone", J. AMER. CHEM. SOC, vol. 77, 1955, pages 4145 - 4149, XP002275444
JONES, J. BRYAN AND GORDON, KEITH D.: "Micellar Aggregation and delat5-3-Keto Steroids Lacking a Polar C-17 Group and Its Relation to the Activity and Specificity of the delta5 to delta4-3-Ketosteroid Isomerase of Pseudomonas testosteroni", BIOCHEMISTRY, VOL. 12, NO. 1, 1973, vol. 12, no. 1, 1973, pages 71 - 76, XP002275445
TSUJI, NATSUKO ET AL.: "Highly Stereoselective Hydrogenation of 3-oxo-4-ene and 1,4-diene Steroids to 5-beta Compounds with Palladium Catalyst", J. ORG. CHEM, vol. 45, 1980, pages 2729 - 2731, XP002275446
HIRSCH A.F. ET AL: "Contagestational Agents. 1. Steroidal O-Aryloximes", J. MEDICINAL CHEMISTRY, vol. 20, no. 12, 1977, pages 1546 - 1551, XP002275447
KEANA, JOHN F. W. ET AL: "Synthesis of a novel cholesterol nitric oxide spin label. Application to the molecular organisation of human high density lipoprotein", J. AMER. CHEM.SOC, vol. 103, no. 16, 1981, pages 4904 - 4912, XP002275442
DJERBASSI ET AL.: "Reaction of Steroidal Sapogenin Spiroketal with Ethanediol", J. ORG. CHEM., vol. 24, no. 1, 3 February 1959 (1959-02-03), pages 1 - 6, XP002275443
SONDHEIMER F. ET AL.: "Steroids. LXVII. The Decarboxylation of Unsaturated Steroidal Acids. Synthesis of 17-Epitestosterone and 17-methylepitestosterone", J. AMER. CHEM. SOC, vol. 77, 1955, pages 4145 - 4149, XP002275444
JONES, J. BRYAN AND GORDON, KEITH D.: "Micellar Aggregation and delat5-3-Keto Steroids Lacking a Polar C-17 Group and Its Relation to the Activity and Specificity of the delta5 to delta4-3-Ketosteroid Isomerase of Pseudomonas testosteroni", BIOCHEMISTRY, VOL. 12, NO. 1, 1973, vol. 12, no. 1, 1973, pages 71 - 76, XP002275445
TSUJI, NATSUKO ET AL.: "Highly Stereoselective Hydrogenation of 3-oxo-4-ene and 1,4-diene Steroids to 5-beta Compounds with Palladium Catalyst", J. ORG. CHEM, vol. 45, 1980, pages 2729 - 2731, XP002275446
HIRSCH A.F. ET AL: "Contagestational Agents. 1. Steroidal O-Aryloximes", J. MEDICINAL CHEMISTRY, vol. 20, no. 12, 1977, pages 1546 - 1551, XP002275447
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