Title:
NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/024932
Kind Code:
A1
Abstract:
Disclosed are compounds, which have excellent effects of inhibiting DGAT and suppressing food intake, or pharmacologically acceptable salts of the same. Specifically disclosed are 4-carboxymethyl-cyclohexyl trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, etc., or pharmacologically acceptable salts of the same.
Inventors:
UTO YOSHIKAZU
KARASAWA HIROSHI
TAKAISHI KIYOSUMI
KARASAWA HIROSHI
TAKAISHI KIYOSUMI
Application Number:
PCT/JP2010/064550
Publication Date:
March 03, 2011
Filing Date:
August 27, 2010
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
UTO YOSHIKAZU
KARASAWA HIROSHI
TAKAISHI KIYOSUMI
UTO YOSHIKAZU
KARASAWA HIROSHI
TAKAISHI KIYOSUMI
International Classes:
C07D217/06; A61K31/472; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P15/08; A61P27/02; A61P43/00
Domestic Patent References:
| WO2007074753A1 | 2007-07-05 | |||
| WO2009119534A1 | 2009-10-01 | |||
| WO2007074753A1 | 2007-07-05 |
Foreign References:
| JP2006045209A | 2006-02-16 | |||
| US20070249620A1 | 2007-10-25 |
Other References:
EIJI ITAGAKI: "STEP series, Metabolism, Endocrinology", 1998, KAIBASHOBO, LTD., pages: 105
ZIMMET, P. ET AL., NATURE, vol. 414, 2001, pages 782 - 787
ENGSTROM, R. G. ET AL., ARCH. INTERN. PHARMACODYN., vol. 214, 1975, pages 308 - 321
BRAY, G. A. ET AL., OBES. RES., vol. 4, 1996, pages 263 - 270
DAVIDSON, M. H. ET AL., THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 281, 1999, pages 235 - 242
COLEMAN, R.; BELL, R., J. BIOL. CHEM., vol. 251, 1976, pages 4537 - 4543
COLEMAN, R., METHODS IN ENZYMOLOGY, vol. 209, 1992, pages 98 - 104
LEHNER, R.; KUKSIS, A., PROG. LIPID RES., vol. 35, 1996, pages 169 - 201
R. BELL., ANN. REV. BIOCHEM., vol. 49, 1980, pages 459 - 487
CASES, S. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 95, 1998, pages 13018 - 13023
CASES, S. ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 38870 - 38876
COLEMAN, R. A.; LEE, D. P., PROGRESS IN LIPID RESEARCH, vol. 43, 2004, pages 134 - 176
SMITH, S. J. ET AL., NAT. GENET., vol. 25, 2000, pages 87 - 90
CHEN, H. C., J. CLIN. INVEST., vol. 109, 2002, pages 1049 - 1055
BUHMAN, K. K., J. BIOL. CHEM., vol. 277, 2002, pages 25474 - 25479
GAZIANO, J. ET AL., CIRCULATION, vol. 96, 1997, pages 2520 - 2525
YAMAGUCHI, K. ET AL., HEPATOLOGY, vol. 47, 2008, pages 625 - 635
STRADER, A. D. ET AL., GASTROENTEROLOGY, vol. 128, 2005, pages 175 - 191
CAMPFIELD, L. A. ET AL., SCIENCE, vol. 269, 1995, pages 546 - 549
J. MED. CHEM., vol. 39, 1996, pages 1084
J. ORG. CHEM., vol. 63, 1998, pages 4116
See also references of EP 2471777A4
ZIMMET, P. ET AL., NATURE, vol. 414, 2001, pages 782 - 787
ENGSTROM, R. G. ET AL., ARCH. INTERN. PHARMACODYN., vol. 214, 1975, pages 308 - 321
BRAY, G. A. ET AL., OBES. RES., vol. 4, 1996, pages 263 - 270
DAVIDSON, M. H. ET AL., THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 281, 1999, pages 235 - 242
COLEMAN, R.; BELL, R., J. BIOL. CHEM., vol. 251, 1976, pages 4537 - 4543
COLEMAN, R., METHODS IN ENZYMOLOGY, vol. 209, 1992, pages 98 - 104
LEHNER, R.; KUKSIS, A., PROG. LIPID RES., vol. 35, 1996, pages 169 - 201
R. BELL., ANN. REV. BIOCHEM., vol. 49, 1980, pages 459 - 487
CASES, S. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 95, 1998, pages 13018 - 13023
CASES, S. ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 38870 - 38876
COLEMAN, R. A.; LEE, D. P., PROGRESS IN LIPID RESEARCH, vol. 43, 2004, pages 134 - 176
SMITH, S. J. ET AL., NAT. GENET., vol. 25, 2000, pages 87 - 90
CHEN, H. C., J. CLIN. INVEST., vol. 109, 2002, pages 1049 - 1055
BUHMAN, K. K., J. BIOL. CHEM., vol. 277, 2002, pages 25474 - 25479
GAZIANO, J. ET AL., CIRCULATION, vol. 96, 1997, pages 2520 - 2525
YAMAGUCHI, K. ET AL., HEPATOLOGY, vol. 47, 2008, pages 625 - 635
STRADER, A. D. ET AL., GASTROENTEROLOGY, vol. 128, 2005, pages 175 - 191
CAMPFIELD, L. A. ET AL., SCIENCE, vol. 269, 1995, pages 546 - 549
J. MED. CHEM., vol. 39, 1996, pages 1084
J. ORG. CHEM., vol. 63, 1998, pages 4116
See also references of EP 2471777A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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