Title:
NSAID-BONDED ALGINIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/060351
Kind Code:
A1
Abstract:
The present invention provides a water-soluble compound that has a function of sustainably releasing a pharmacologically active ingredient in vivo and is usable in a sustained release preparation. A sustained release derivative wherein: alginic acid or a salt thereof is bonded to a nonsteroidal anti-inflammatory compound via a linker having a specific structure; one end of the linker and alginic acid together form an amide bond via a nitrogen atom; and the other end of the linker and the nonsteroidal anti-inflammatory compound together form an ester bond via an oxygen atom. When used as an active ingredient of a sustained release preparation, this derivative can stably release the nonsteroidal anti-inflammatory compound at an affected area over a long period of time to thereby exert a long-lasting effect.
Inventors:
SAKURADA ISAO (JP)
SUZUKI YUTA (JP)
KUDO TAKASHI (JP)
FURUSAKO SHOJI (JP)
SUZUKI YUTA (JP)
KUDO TAKASHI (JP)
FURUSAKO SHOJI (JP)
Application Number:
PCT/JP2020/035967
Publication Date:
April 01, 2021
Filing Date:
September 24, 2020
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
International Classes:
A61K45/00; A61K9/06; A61K31/192; A61K31/196; A61K47/61; A61P19/02; A61P29/00; C08B37/04
Domestic Patent References:
| WO2019182015A1 | 2019-09-26 | |||
| WO2007004675A1 | 2007-01-11 | |||
| WO2005066214A1 | 2005-07-21 | |||
| WO2005026214A1 | 2005-03-24 |
Foreign References:
| JPH04505334A | 1992-09-17 |
Other References:
THE PRACTICE OF MEDICINAL CHEMISTRY, vol. 2, 1999, pages 328
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (JP)
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