Title:
NUCLEAR HORMONE RECEPTOR LIGAND BINDING DOMAINS
Document Type and Number:
WIPO Patent Application WO2002070559
Kind Code:
A3
Abstract:
This invention relates to the novel proteins, termed LBDG1 and LBDG4, herein identified as Nuclear Hormone Receptor Ligand Binding Domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
More Like This:
Inventors:
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
POTTER SARAH JANE (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
POTTER SARAH JANE (GB)
Application Number:
PCT/GB2002/000948
Publication Date:
April 03, 2003
Filing Date:
March 05, 2002
Export Citation:
Assignee:
INPHARMATICA LTD (GB)
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
POTTER SARAH JANE (GB)
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
POTTER SARAH JANE (GB)
International Classes:
A61K31/7088; A61K35/76; A61K38/00; A01K67/027; A61K39/00; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/14; A61P5/00; A61P5/14; A61P7/00; A61P7/02; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/10; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K14/705; C07K14/72; C07K16/28; C12M1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N37/00; (IPC1-7): C07K14/705; C07K14/72; A61K38/17
Domestic Patent References:
| WO1998049276A1 | 1998-11-05 |
Other References:
BURRIS THOMAS P ET AL: "The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily.", RECENT PROGRESS IN HORMONE RESEARCH, vol. 51, 1996, Conference;Skamania, Washington, USA; 1995, 1996 The Endocrine Society 9650 Rockville Pike, Bethesda, Maryland 20814, USA, pages 241 - 260, XP001105530, ISBN: 1-879225-22-0
SEOL WONGI ET AL: "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.", SCIENCE (WASHINGTON D C), vol. 272, no. 5266, 1996, pages 1336 - 1339, XP001093740, ISSN: 0036-8075
KUROYANAGI HIDEHITO ET AL: "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.", GENOMICS, vol. 51, no. 1, 1 July 1998 (1998-07-01), pages 76 - 85, XP002214556, ISSN: 0888-7543
SEIELSTAD D A ET AL: "ANALYSIS OF THE STRUCTURAL CORE OF THE HUMAN ESTROGEN RECEPTOR LIGAND BINDING DOMAIN BY SELECTIVE PROTEOLYSIS/MASS SPECTROMETRIC ANALYSIS", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 39, 1995, pages 12605 - 12615, XP002063749, ISSN: 0006-2960
SEOL WONGI ET AL: "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.", SCIENCE (WASHINGTON D C), vol. 272, no. 5266, 1996, pages 1336 - 1339, XP001093740, ISSN: 0036-8075
KUROYANAGI HIDEHITO ET AL: "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.", GENOMICS, vol. 51, no. 1, 1 July 1998 (1998-07-01), pages 76 - 85, XP002214556, ISSN: 0888-7543
SEIELSTAD D A ET AL: "ANALYSIS OF THE STRUCTURAL CORE OF THE HUMAN ESTROGEN RECEPTOR LIGAND BINDING DOMAIN BY SELECTIVE PROTEOLYSIS/MASS SPECTROMETRIC ANALYSIS", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 39, 1995, pages 12605 - 12615, XP002063749, ISSN: 0006-2960
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