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Title:
A NUCLEIC ACID ANALYSIS METHOD AND APPARATUS
Document Type and Number:
WIPO Patent Application WO/2015/091139
Kind Code:
A3
Abstract:
Methods of detecting target nucleic acid is a sample are described. A first probe is attached to first beads, and the first beads are placed in the sample so that any target nucleic acid attaches to the first probe. A second probe also attaches to the target nucleic acid so that any of the target nucleic acid links or "tethers" the first and second probes. A capacitive sensor detects capacitance of the beads and processes capacitance data to quantify target nucleic acid presence in the sample. The second probe may be immobilised on the sensor surface. Alternatively the second beads are introduced into the sample with the second probe attached, and the extent of tethering of the first beads to the second beads is indicative of the extent of target NA present.

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Inventors:
CUMMINS TIMOTHY (IE)
O'FARRELL BRIAN (IE)
Application Number:
PCT/EP2014/077185
Publication Date:
August 13, 2015
Filing Date:
December 10, 2014
Export Citation:
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Assignee:
ALTRA TECH LTD (IE)
International Classes:
C12Q1/68; G01N27/22; G01R27/26
Domestic Patent References:
WO1999027367A11999-06-03
WO2011017660A22011-02-10
WO2007106579A22007-09-20
WO2001009388A12001-02-08
Foreign References:
US20100267162A12010-10-21
Other References:
CHAVIDI VENKATA PRASAD ET AL: "Formulation and Characterization of Sodium Alginate g-Hydroxy Ethylacrylate Bio-Degradable Polymeric Beads: In Vitro Release Studies", JOURNAL OF POLYMERS AND THE ENVIRONMENT ; FORMERLY: 'JOURNAL OF ENVIRONMENTAL POLYMER DEGRADATION', KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 20, no. 2, 29 January 2012 (2012-01-29), pages 344 - 352, XP035056083, ISSN: 1572-8900, DOI: 10.1007/S10924-011-0401-6
Attorney, Agent or Firm:
WELDON, Michael et al. (Third Floor,,Duncairn House,,14 Carysfort Avenue,,Blackroc, County Dublin 01, IE)
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