Title:
NUCLEIC ACID COMPLEX FOR MODULATING IHH EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2020/184700
Kind Code:
A1
Abstract:
Provided are a nucleic acid complex and a method for lowering the expression of IHH gene mRNA and protein in an animal. The nucleic acid complex for lowering the expression of IHH gene mRNA and protein acts as a specific inhibitor of the IHH gene and is therefore useful in elucidating IHH gene function. A specific inhibitor of the IHH gene is also useful in treating, preventing, improving, or slowing the advance of fibrosis and fibrotic disease. This nucleic acid complex specifically inhibits expression of the IHH gene and is therefore useful in patients who require treatment, prevention, improvement, or slowing of the advance of fibrosis and fibrotic disease.
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Inventors:
KIZAWA HIDEKI (JP)
TAKAGI KO (JP)
TAKAGI KO (JP)
Application Number:
PCT/JP2020/011018
Publication Date:
September 17, 2020
Filing Date:
March 13, 2020
Export Citation:
Assignee:
RENA THERAPEUTICS INC (JP)
International Classes:
A61K45/00; A61K31/7088; A61K48/00; A61P1/16; A61P1/18; A61P11/00; A61P13/12; A61P17/00; A61P43/00; C12N15/113; C12N15/12
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Other References:
ALESSIA OMENETTI ET AL., J. HEPATOL., vol. 54, no. 2, 2011, pages 366 - 373
JAMES PRITCHETT ET AL., HEPATOLOGY, vol. 56, no. 3, 2012, pages 1108 - 1116
TAO LI ET AL., INT. J. CLIN. EXP. PATHOL., vol. 8, no. 11, 2015, pages 14574 - 14579
ANGULO P. ET AL., SEMIN LIVER DIS., vol. 35, no. 2, 2015, pages 132 - 45
WANG X. ET AL., CELL METABOLISM, vol. 24, 2016, pages 848 - 862
"NCBI", Database accession no. NM_010544.3
NAT. COMMUN., vol. 6, 10 August 2015 (2015-08-10), pages 7969
See also references of EP 3981431A4
JAMES PRITCHETT ET AL., HEPATOLOGY, vol. 56, no. 3, 2012, pages 1108 - 1116
TAO LI ET AL., INT. J. CLIN. EXP. PATHOL., vol. 8, no. 11, 2015, pages 14574 - 14579
ANGULO P. ET AL., SEMIN LIVER DIS., vol. 35, no. 2, 2015, pages 132 - 45
WANG X. ET AL., CELL METABOLISM, vol. 24, 2016, pages 848 - 862
"NCBI", Database accession no. NM_010544.3
NAT. COMMUN., vol. 6, 10 August 2015 (2015-08-10), pages 7969
See also references of EP 3981431A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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