NUCLEIC-ACID-CONTAINING NANOPARTICLES - KYOWA HAKKO KIRIN CO LTD

Title:

NUCLEIC-ACID-CONTAINING NANOPARTICLES

Document Type and Number:

WIPO Patent Application WO/2018/225873

Kind Code:

A1

Abstract:

The present invention pertains to nanoparticles containing: a lipid (lipid I) that includes a lipid- or water-soluble unit and has a ligand capable of binding to Siglec (sialic acid-binding immunoglobulin-like lectin), and a nucleic acid; or a polymer (polymer I) that includes a water-soluble unit and a cationic unit and has a ligand capable of binding to Siglec (sialic acid-binding immunoglobulin-like lectin), and a nucleic acid. These nanoparticles are nucleic acid-containing nanoparticles that can be delivered to immune system cells.

Inventors:

UEHARA KEIJI (JP)
HATANAKA KENTARO (JP)
IWAI HIROTO (JP)
NAOI TOMOYUKI (JP)
DESTITO GIUSEPPE (US)
NUGENT RACHEL SOLOFF (US)

Application Number:

PCT/JP2018/022286

Publication Date:

December 13, 2018

Filing Date:

June 11, 2018

Export Citation:

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Assignee:

KYOWA HAKKO KIRIN CO LTD (JP)

International Classes:

A61K31/7105; A61K9/14; A61K47/14; A61P43/00

Domestic Patent References:

WO2016153012A1	2016-09-29
WO2015164818A1	2015-10-29

Foreign References:

JP2016519120A	2016-06-30
JP2015521040A	2015-07-27
JP2011500023A	2011-01-06

Other References:

PRESCHER, HORST ET AL.: "New human CD 22/siglec-2 ligands with a triazole glycoside", CHEM BIO CHEM, vol. 18, no. 13, 19 May 2017 (2017-05-19), pages 1216 - 1225, XP055561010, Retrieved from the Internet
SPENCE, S. ET AL.: "Targeting siglecs with a sialic acid- decorated nanoparticle abrogates inflammation", SCI TRANSL MED, vol. 7, no. 303, 2 September 2015 (2015-09-02), pages 303ra140, XP055561012, Retrieved from the Internet
KISO, MAKOTO: "Regarding structure and function of sugar chain (no. 2", JOURNAL OF JAPAN SOY SAUCE RESEARCH INSTITUTE - ZAIDAN HOJIN NIHON SHOYU KENKYUSHO, vol. 30, no. 3, 2004, pages 77 - 84