Title:
NUCLEIC ACID FOR CONTROLLING GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2019/194236
Kind Code:
A1
Abstract:
The present invention provides a nucleic acid with which the expression amount of a target gene can be controlled. The nucleic acid according to the present invention comprises (i) a base sequence represented by 5'-[T(G/A)ACATG(A/C)T]n-3' (in the base acid sequence, n is an integer of 1-20) or (ii) a base sequence obtained by substituting, adding or deleting at least one base in the aforementioned base sequence. The expression amount of a gene positioned downstream on the base sequence can be adjusted.
Inventors:
SUENAGA HIKARU (JP)
MATSUZAWA TOMOHIKO (JP)
SAHARA TAKEHIKO (JP)
MATSUZAWA TOMOHIKO (JP)
SAHARA TAKEHIKO (JP)
Application Number:
PCT/JP2019/014846
Publication Date:
October 10, 2019
Filing Date:
April 03, 2019
Export Citation:
Assignee:
AIST (JP)
International Classes:
C12N15/113; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/00
Foreign References:
| JP2002507205A | 2002-03-05 |
Other References:
ATTIA, A. S. ET AL.: "A conserved tetranucleotide repeat is necessary for wild-type expression of the Moraxella catarrhalis UspA2 protein", J. BACTERIOL., vol. 188, 2006, pages 7840 - 7852, XP055644912
ZHOU, K. ET AL.: "The role of variable DNA tandem repeats in bacterial adaptation", FEMS MICROBIOL. REV., vol. 38, 2014, pages 119 - 141, XP055644914
ZHOU, K. ET AL.: "The role of variable DNA tandem repeats in bacterial adaptation", FEMS MICROBIOL. REV., vol. 38, 2014, pages 119 - 141, XP055644914
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