Title:
NUCLEOTIDE COMPOUNDS AND METHOD OF SYNTHESIZING OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/1999/021872
Kind Code:
A1
Abstract:
Novel nucleotide compounds represented by general formula (I) or (II) and a method of synthesizing oligonucleotides, in particular, di- to hexameric block compounds therefrom, wherein B represents a nucleic acid base protected, if necessary, with a suitable protective group; R represents a hydroxy-protecting group; X represents hydrogen, optionally protected hydroxy, or alkoxy; and Y¿1? and Y¿2? may be the same or different and each represents a heterocyclic residue.
Inventors:
MORI KENYA (JP)
YAMADA KOHEI (JP)
MIYASHITA TAKANORI (JP)
YAMADA KOHEI (JP)
MIYASHITA TAKANORI (JP)
Application Number:
PCT/JP1998/004715
Publication Date:
May 06, 1999
Filing Date:
October 20, 1998
Export Citation:
Assignee:
YAMASA CORP (JP)
MORI KENYA (JP)
YAMADA KOHEI (JP)
MIYASHITA TAKANORI (JP)
MORI KENYA (JP)
YAMADA KOHEI (JP)
MIYASHITA TAKANORI (JP)
International Classes:
C07H19/04; C07H19/10; C07H19/20; (IPC1-7): C07H19/06; C07H19/16; C07H21/00
Other References:
UZNANSKI B., WILK A., STEC W. J.: "DEOXYRIBONUCLEOSIDE 3'-PHOSPHORDIAMIDITES AS SUBSTRATES FOR SOLID SUPPORTED SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES AND THEIR PHOSPHORO-THIOATE AND DNA-TRIESTER ANALOGUES.", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 28., no. 29., 1 January 1987 (1987-01-01), GB, pages 3401 - 3404., XP002915793, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)95524-2
OZAKI H., ET AL.: "SYNTHESIS OF BIS(DEOXYRIBONUCLEOSIDE) PHOSPHOROMORPHOLIDATE DERIVATIVES FOR OLIGODEOXYRIBONUCLEOTIDE PREPARATION BY USE OF A SELECTIVE PHOSPHITYLATING REAGENT.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 62., no. 12., 1 December 1989 (1989-12-01), JP, pages 3869 - 3876., XP002915794, ISSN: 0009-2673
BRILL W. K.-D., YAU E. K., CARUTHERS M. H.: "OXIDATIVE AND NONOXIDATIVE-FORMATION OF INTERNUCLEOTIDE LINKAGES.", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 30., no. 48., 1 January 1989 (1989-01-01), GB, pages 6621 - 6624., XP002915795, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)70634-4
OZAKI H., ET AL.: "SYNTHESIS OF BIS(DEOXYRIBONUCLEOSIDE) PHOSPHOROMORPHOLIDATE DERIVATIVES FOR OLIGODEOXYRIBONUCLEOTIDE PREPARATION BY USE OF A SELECTIVE PHOSPHITYLATING REAGENT.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 62., no. 12., 1 December 1989 (1989-12-01), JP, pages 3869 - 3876., XP002915794, ISSN: 0009-2673
BRILL W. K.-D., YAU E. K., CARUTHERS M. H.: "OXIDATIVE AND NONOXIDATIVE-FORMATION OF INTERNUCLEOTIDE LINKAGES.", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 30., no. 48., 1 January 1989 (1989-01-01), GB, pages 6621 - 6624., XP002915795, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)70634-4
Attorney, Agent or Firm:
Sato, Kazuo (Room 323 2-3, Marunouchi 3-chome Chiyoda-ku Tokyo, JP)
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