Title:
OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES
Document Type and Number:
WIPO Patent Application WO/1995/018623
Kind Code:
A1
Abstract:
Novel compounds and libraries of compounds based on nitrogen atoms that are joined together with spanner groups include "letters", i.e. functional groups, that are attached to the nitrogen atoms, to the spanner groups or to both the nitrogen atoms and the spanner groups to render the compounds and libraries of such compounds with diverse properties.
Inventors:
COOK PHILLIP DAN (US)
SANGHVI YOGESH S (US)
KUNG PEI PEI (US)
SANGHVI YOGESH S (US)
KUNG PEI PEI (US)
Application Number:
PCT/US1995/000350
Publication Date:
July 13, 1995
Filing Date:
January 11, 1995
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
COOK PHILLIP DAN (US)
SANGHVI YOGESH S (US)
KUNG PEI PEI (US)
COOK PHILLIP DAN (US)
SANGHVI YOGESH S (US)
KUNG PEI PEI (US)
International Classes:
C12N15/09; A61K31/13; A61K31/395; A61K31/505; A61K31/52; A61K31/522; A61K47/48; A61P43/00; C07B43/00; C07C209/60; C07C211/09; C07C211/13; C07C211/15; C07C211/16; C07C211/20; C07C211/25; C07C211/26; C07C211/34; C07C211/39; C07C239/08; C07C243/10; C07D209/48; C07D233/24; C07D239/47; C07D273/00; C07D405/04; C07D405/14; C07D473/18; C07D473/34; C07F7/18; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H21/00; C08G73/00; C08G73/02; C08G75/30; C12N15/113; C12Q1/68; (IPC1-7): A61K31/74; A61K31/755; A61K31/765; A61K31/785; A61K31/795; A61K31/80; A61K33/04; C08G73/00; C12N15/11
Foreign References:
| US4264562A | 1981-04-28 | |||
| US5142047A | 1992-08-25 |
Other References:
SCIENCE, Volume 258, issued 27 November 1992, J. HANVEY et al., "Antisense and Antigene Properties of Peptide Nucleic Acids", pages 1481-1485.
NATURE, Volume 217, issued 17 February 1968, M. HALFORD et al., "Synthetic Analogues of Polynucleotides", pages 638-640.
NUCLEIC ACIDS RESEARCH, Volume 19, No. 10, issued 1991, K. AUGUSTYNS et al., "Influence of the Incorporation of (S)-9-(3,4-Dihydroxy-Butyl)Adenine on the Enzymatic Stability and Base-Pairing Properties of Oligodeoxynucleotides", pages 2587-2593.
ADVANCES IN POLYMER SCIENCE, Volume 50, issued 1983, J. PITHA, "Physiological Activities of Synthetic Analogs of Polynucleotides", pages 2-16.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Volume 114, issued 1992, R. ZUCKERMAN et al., "Efficient Method for the Preparation of Peptoids [Oligo(N-Substituted Glycines)] by Submonomer Solid-Phase Synthesis", pages 10646-10647.
CHEMICAL AND PHARMACOLOGICAL BULLETIN, Volume 34, No. 3, issued 1986, M. NIITSU et al., "Synthesis of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals", pages 1032-1038.
TETRAHEDRON LETTERS, Volume 31, No. 39, issued 1990, A. ABDEL-MAGID et al., "Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride", pages 5595-5598.
See also references of EP 0746326A4
NATURE, Volume 217, issued 17 February 1968, M. HALFORD et al., "Synthetic Analogues of Polynucleotides", pages 638-640.
NUCLEIC ACIDS RESEARCH, Volume 19, No. 10, issued 1991, K. AUGUSTYNS et al., "Influence of the Incorporation of (S)-9-(3,4-Dihydroxy-Butyl)Adenine on the Enzymatic Stability and Base-Pairing Properties of Oligodeoxynucleotides", pages 2587-2593.
ADVANCES IN POLYMER SCIENCE, Volume 50, issued 1983, J. PITHA, "Physiological Activities of Synthetic Analogs of Polynucleotides", pages 2-16.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Volume 114, issued 1992, R. ZUCKERMAN et al., "Efficient Method for the Preparation of Peptoids [Oligo(N-Substituted Glycines)] by Submonomer Solid-Phase Synthesis", pages 10646-10647.
CHEMICAL AND PHARMACOLOGICAL BULLETIN, Volume 34, No. 3, issued 1986, M. NIITSU et al., "Synthesis of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals", pages 1032-1038.
TETRAHEDRON LETTERS, Volume 31, No. 39, issued 1990, A. ABDEL-MAGID et al., "Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride", pages 5595-5598.
See also references of EP 0746326A4
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