Title:
OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO2003068798
Kind Code:
A3
Abstract:
The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.
Inventors:
EFIMOV VLADIMIR (RU)
FERNANDEZ JOSEPH (US)
ARCHDEACON DOROTHY (US)
ARCHDEACHON JOHN (US)
CHOOB MIKHAIL (US)
FERNANDEZ JOSEPH (US)
ARCHDEACON DOROTHY (US)
ARCHDEACHON JOHN (US)
CHOOB MIKHAIL (US)
Application Number:
PCT/US2003/003904
Publication Date:
April 22, 2004
Filing Date:
February 07, 2003
Export Citation:
Assignee:
ACTIVE MOTIF (US)
EFIMOV VLADIMIR (RU)
FERNANDEZ JOSEPH (US)
ARCHDEACON DOROTHY (US)
ARCHDEACHON JOHN (US)
CHOOB MIKHAIL (US)
EFIMOV VLADIMIR (RU)
FERNANDEZ JOSEPH (US)
ARCHDEACON DOROTHY (US)
ARCHDEACHON JOHN (US)
CHOOB MIKHAIL (US)
International Classes:
C07H21/00; C07K14/00; C12N15/113; (IPC1-7): C12Q1/68; C07H21/02
Domestic Patent References:
| WO2001068673A1 | 2001-09-20 |
Foreign References:
| US6015887A | 2000-01-18 |
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