Title:
OPHTHALMIC COMPOSITIONS AND METHODS FOR SUSTAINED DRUG RELEASE
Document Type and Number:
WIPO Patent Application WO/2024/069230
Kind Code:
A3
Abstract:
Embodiments of the disclosure provide ophthalmic compositions and methods of use thereof. The embodiments disclose ophthalmic compositions including devices such as a punctal plug. Some embodiments are directed to a method of preparing and using such devices. One embodiment provides a method of dissolving a hydrophilic polymer and an active pharmaceutical ingredient (API) in alcohol to form a hydrophilic polymer/API solution, where the API includes tacrolimus, spray drying the hydrophilic polymer/API solution to form a hydrophilic polymer/API mixture, mixing the hydrophilic polymer/API mixture with a binder to form an API paste, and curing the API paste to form a punctal plug, where the punctal plug is configured to release an effective amount of the API for a treatment period of 30 days to one year.
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Inventors:
SHEETRIT EYAL (IL)
TOMER GUY (IL)
TOMER GUY (IL)
Application Number:
PCT/IB2023/000577
Publication Date:
May 10, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
EXIMORE LTD (IL)
International Classes:
A61K31/436; A61F9/00; A61K9/00; A61K31/435; A61K47/08; A61K47/34; A61K47/38; A61P27/02
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