Title:
OPTICALLY ACTIVE 1-ARYL-2-FLUORO-SUBSTITUTED ETHYLAMINE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2005/085174
Kind Code:
A1
Abstract:
Disclosed is a method for producing an optically active 1-aryl-2-fluoro-substituted ethylamine represented by the following general formula [2]: [wherein Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] or a salt thereof by hydrogenolyzing an optically active secondary amine represented by the following general formula [1]: [wherein Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] or a salt thereof in the presence of a group VIII transition metal catalyst.
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Inventors:
ISHII AKIHIRO
KANAI MASATOMI
KURIYAMA YOKUSU
YASUMOTO MANABU
INOMIYA KENJIN
OOTSUKA TAKASHI
SUTO KATSUHIDE
UEDA KOJI
KANAI MASATOMI
KURIYAMA YOKUSU
YASUMOTO MANABU
INOMIYA KENJIN
OOTSUKA TAKASHI
SUTO KATSUHIDE
UEDA KOJI
Application Number:
PCT/JP2005/002740
Publication Date:
September 15, 2005
Filing Date:
February 21, 2005
Export Citation:
Assignee:
CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
KANAI MASATOMI
KURIYAMA YOKUSU
YASUMOTO MANABU
INOMIYA KENJIN
OOTSUKA TAKASHI
SUTO KATSUHIDE
UEDA KOJI
ISHII AKIHIRO
KANAI MASATOMI
KURIYAMA YOKUSU
YASUMOTO MANABU
INOMIYA KENJIN
OOTSUKA TAKASHI
SUTO KATSUHIDE
UEDA KOJI
International Classes:
C07B61/00; C07C209/52; C07C209/60; C07C209/62; C07C211/29; C07C249/02; C07C251/24; C07C209/26; (IPC1-7): C07C209/62; C07C209/52; C07C211/29; C07C249/02; C07C251/24
Domestic Patent References:
| WO2002050056A1 | 2002-06-27 |
Other References:
TOROK B. ET AL: "Synthesis of Chiral Trifluoromethylated Amines by Palladium-Catalyzed Diasteroselective Hydrogenation-Hydrogenolysis.", ADVANCED SYNTHESIS & CATALYSIS., vol. 345, no. 1+2, 2003, pages 165 - 168, XP002989156
PIRKLE W.H. ET AL: "Design of Chiral Derivatizing Agents for the Chromatographic Resolution of Optical Isomers. Asymetric Synthesis of Some Chiral Fluoroalkylated Amines.", JOURNAL OF ORGANIC CHEMISTRY., vol. 42, no. 14, 1977, pages 2436 - 2439, XP002989157
KATO K. ET AL: "Enzymatic resolution of 2,2,2,-trifluoro-1-arylethylamine derivatives by Pseudomonas fluorescens lipase in organic solvents.", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC., vol. 30, 3 August 2004 (2004-08-03), pages 61 - 68, XP002989158
See also references of EP 1721887A4
PIRKLE W.H. ET AL: "Design of Chiral Derivatizing Agents for the Chromatographic Resolution of Optical Isomers. Asymetric Synthesis of Some Chiral Fluoroalkylated Amines.", JOURNAL OF ORGANIC CHEMISTRY., vol. 42, no. 14, 1977, pages 2436 - 2439, XP002989157
KATO K. ET AL: "Enzymatic resolution of 2,2,2,-trifluoro-1-arylethylamine derivatives by Pseudomonas fluorescens lipase in organic solvents.", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC., vol. 30, 3 August 2004 (2004-08-03), pages 61 - 68, XP002989158
See also references of EP 1721887A4
Attorney, Agent or Firm:
Hashimoto, Takeshi c/o Shiga, Patent Office (Ekisaikai Bldg. 1-29, Akashi-ch, Chuo-ku Tokyo 44, JP)
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