Title:
ORAL PHARMACEUTICAL COMPOSITION CONTAINING PEMETREXED AND PRODUCTION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/117441
Kind Code:
A1
Abstract:
The present invention relates to an oral pharmaceutical composition which contains the water-soluble, anti-cancer drug pemetrexed and a production method thereof, and more specifically, to an oral pharmaceutical composition wherein a complex is formed by the ionic coupling of a bile acid derivative which is an oral absorption enhancer with pemetrexed, the complex is included in a pharmaceutical additive and then pressed into capsule or tablet form, or is mixed with the internal aqueous phase of a water-in-oil-in-water (w/o/w) multi-emulsion nano-emulsion so as to improve the oral bioavailability of the water-soluble anti-cancer drug pemetrexed, thereby allowing production in an orally administrable form of pemetrexed, which is currently only administered in injection form, thereby ameliorating the inconvenience and problems with use of an injection, and can contribute to improving patient compliance and reducing medical costs.
Inventors:
PARK JIN WOO (KR)
BYUN YOUNG RO (KR)
CHOI YOUNG KWEON (KR)
CHANG KWAN YOUNG (KR)
LEE JAE BUM (KR)
BYUN YOUNG RO (KR)
CHOI YOUNG KWEON (KR)
CHANG KWAN YOUNG (KR)
LEE JAE BUM (KR)
Application Number:
PCT/KR2018/011885
Publication Date:
June 20, 2019
Filing Date:
October 10, 2018
Export Citation:
Assignee:
IPHAMA CO LTD (KR)
International Classes:
A61K9/00; A61K9/113; A61K9/20; A61K9/48; A61K31/519; A61K47/54
Domestic Patent References:
| WO2016178224A1 | 2016-11-10 |
Foreign References:
| US20080026077A1 | 2008-01-31 | |||
| JP2009514874A | 2009-04-09 | |||
| KR20150020266A | 2015-02-25 | |||
| KR101260636B1 | 2013-05-13 |
Other References:
PANGENI, RUDRA: "Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation", INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, pages 6379 - 6399, XP055558169, doi:10.2147/IJN.S121114
LEE, S. ET AL.: "A new drug carrier, Nalpha-deoxycholyl-L-lysyl-methylester, for enhancing insulin absorption in the intestine", DIABETOLOGIA, vol. 48, no. 3, 1 March 2005 (2005-03-01), pages 405 - 411, XP019322467
LEE, S. ET AL.: "A new drug carrier, Nalpha-deoxycholyl-L-lysyl-methylester, for enhancing insulin absorption in the intestine", DIABETOLOGIA, vol. 48, no. 3, 1 March 2005 (2005-03-01), pages 405 - 411, XP019322467
Attorney, Agent or Firm:
DAWOOL PATENT AND LAW FIRM (KR)
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