Title:
OSTEOGENIC COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/092169
Kind Code:
A1
Abstract:
Provided is a composition having a cell-derived physiological activity. The osteogenic composition according to the present invention contains a processed product of megakaryocytes or a culture thereof.
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Inventors:
IWATAKE MAYUMI (JP)
SUMITA YOSHINORI (JP)
ASAHINA IZUMI (JP)
SATAKE MAKOTO (JP)
HAZAMA YASUKO (JP)
SUMITA YOSHINORI (JP)
ASAHINA IZUMI (JP)
SATAKE MAKOTO (JP)
HAZAMA YASUKO (JP)
Application Number:
PCT/JP2021/039716
Publication Date:
May 05, 2022
Filing Date:
October 27, 2021
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
MEGAKARYON CORP (JP)
MEGAKARYON CORP (JP)
International Classes:
A61K35/19; A61K38/17; A61L27/38; A61P19/00; C12N5/0775; C12N5/078; C12N5/16; C12N15/12; C07K14/47
Domestic Patent References:
| WO2017065280A1 | 2017-04-20 | |||
| WO2019059235A1 | 2019-03-28 | |||
| WO2019189947A1 | 2019-10-03 | |||
| WO2021117900A1 | 2021-06-17 | |||
| WO2011034073A1 | 2011-03-24 | |||
| WO2012157586A1 | 2012-11-22 | |||
| WO2014123242A1 | 2014-08-14 | |||
| WO2017065280A1 | 2017-04-20 |
Foreign References:
| JP2012120529A | 2012-06-28 | |||
| US20120238023A1 | 2012-09-20 | |||
| US20140127815A1 | 2014-05-08 | |||
| US20160002599A1 | 2016-01-07 | |||
| US20180282697A1 | 2018-10-04 | |||
| JP2020180042A | 2020-11-05 |
Other References:
CHEVALLIER, N. et al. Osteoblastic differentiation of human mesenchymal stem cells with platelet lysate. Biomaterials. 2010, 31(2), p. 270-8
SATO MASASHI, SHIGA YASUHIRO, TAKAYAMA NAOYA, SONE MASAMITSU, KOSAKA KENTARO, MOTEGI ITSURO, MIZUKI NORICHIKA, INAGE KAZUHIDE, EGU: "The Effect of Megakaryocytes and Platelets Derived from Human-Induced Pluripotent Stem Cells on Bone Formation", SPINE SURGERY AND RELATED RESEARCH, vol. 5, no. 3, 27 May 2021 (2021-05-27), pages 196 - 204, XP055926740, DOI: 10.22603/ssrr.2020-0226
HIDEYUKI OGURO: "Senescence and aging of stem cells regulated by polycomb complexes", REGENERATIVE MEDICINE, vol. 6, no. 4, 2007, pages 26 - 32
JESUS GIL: "Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all", NATURE REVIEWS MOLECULAR CELL BIOLOGY, vol. 7, 2007, pages 667 - 677, XP037922534, DOI: 10.1038/nrm1987
SOO-HYUN KIM: "Absence of pl6INK4a and truncation of ARF tumor suppressors in chickens", PNAS, vol. 100, no. 1, 2003, pages 211 - 216
TOSHIHARU HASE: "Basic Principles and Experiments in Protein Science 1, Protein Production: Extraction, Purification, and Synthesis", 13 December 2008, COMPANY, INC.
"Immunoassay: from Basics to Advanced Techniques", 20 December 2014, KODANSHA LTD.
ANN-KATHRIN BORGER: "Generation of HLA-Universal iPSC-Derived Megakaryocytes and Platelets for Survival Under Refractoriness Conditions", MOL. MED., vol. 22, 2016, pages 274 - 288
NAKAMURA S ET AL.: "Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells", CELL STEM CELL, vol. 14, no. 4, 2014, pages 535 - 548, XP055567214, DOI: 10.1016/j.stem.2014.01.011
TAKAYAMA N. ET AL.: "Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells", J. EXP. MED., vol. 13, 2010, pages 2817 - 2830
KOBAYASHI, T. ET AL.: "Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.", CELL, vol. 142, no. 5, 2010, pages 787 - 799, XP055053670, DOI: 10.1016/j.cell.2010.07.039
SATO MASASHI, SHIGA YASUHIRO, TAKAYAMA NAOYA, SONE MASAMITSU, KOSAKA KENTARO, MOTEGI ITSURO, MIZUKI NORICHIKA, INAGE KAZUHIDE, EGU: "The Effect of Megakaryocytes and Platelets Derived from Human-Induced Pluripotent Stem Cells on Bone Formation", SPINE SURGERY AND RELATED RESEARCH, vol. 5, no. 3, 27 May 2021 (2021-05-27), pages 196 - 204, XP055926740, DOI: 10.22603/ssrr.2020-0226
HIDEYUKI OGURO: "Senescence and aging of stem cells regulated by polycomb complexes", REGENERATIVE MEDICINE, vol. 6, no. 4, 2007, pages 26 - 32
JESUS GIL: "Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all", NATURE REVIEWS MOLECULAR CELL BIOLOGY, vol. 7, 2007, pages 667 - 677, XP037922534, DOI: 10.1038/nrm1987
SOO-HYUN KIM: "Absence of pl6INK4a and truncation of ARF tumor suppressors in chickens", PNAS, vol. 100, no. 1, 2003, pages 211 - 216
TOSHIHARU HASE: "Basic Principles and Experiments in Protein Science 1, Protein Production: Extraction, Purification, and Synthesis", 13 December 2008, COMPANY, INC.
"Immunoassay: from Basics to Advanced Techniques", 20 December 2014, KODANSHA LTD.
ANN-KATHRIN BORGER: "Generation of HLA-Universal iPSC-Derived Megakaryocytes and Platelets for Survival Under Refractoriness Conditions", MOL. MED., vol. 22, 2016, pages 274 - 288
NAKAMURA S ET AL.: "Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells", CELL STEM CELL, vol. 14, no. 4, 2014, pages 535 - 548, XP055567214, DOI: 10.1016/j.stem.2014.01.011
TAKAYAMA N. ET AL.: "Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells", J. EXP. MED., vol. 13, 2010, pages 2817 - 2830
KOBAYASHI, T. ET AL.: "Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.", CELL, vol. 142, no. 5, 2010, pages 787 - 799, XP055053670, DOI: 10.1016/j.cell.2010.07.039
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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