Title:
OXALIC ACID MONOAMIDE LIGAND, AND USES THEREOF IN COUPLING REACTION OF COPPER-CATALYZED ARYL HALOGEN SUBSTITUTE
Document Type and Number:
WIPO Patent Application WO/2017/012379
Kind Code:
A1
Abstract:
The present invention provides an oxalic acid monoamide ligand, and uses thereof in a coupling reaction of a copper-catalyzed aryl halogen substitute. Specifically, the present invention provides uses of a compound represented by formula I, wherein definitions of radical groups are described in the specifications. The compound represented by formula I can be used as a ligand of a coupling reaction of a copper-catalyzed aryl halogen substitute, and is used for catalyzing a coupling reaction for forming an aryl halogen substitute comprising C-N, C-O and C-S bonds.
More Like This:
Inventors:
MA DAWEI (CN)
ZHOU WEI (CN)
FAN MENGYANG (CN)
WU HAIBO (CN)
YIN JUNLI (CN)
XIA SHANGHUA (CN)
ZHOU WEI (CN)
FAN MENGYANG (CN)
WU HAIBO (CN)
YIN JUNLI (CN)
XIA SHANGHUA (CN)
Application Number:
PCT/CN2016/079500
Publication Date:
January 26, 2017
Filing Date:
April 15, 2016
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
B01J31/22; C07C231/02; C07C233/56
Foreign References:
| CN104610088A | 2015-05-13 | |||
| CN102159534A | 2011-08-17 |
Other References:
MAHA, H. ET AL.: "Ligand-Based Modelling Followed by Synthetic Exploration Unveil Novel Glycogen Phosphorylase Inhibitory Leads", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 16, 7 July 2011 (2011-07-07), pages 4746 - 4771, XP028252895, ISSN: 0968-0896
KAJAL, C. ET AL.: "Chemical Hybridizing Agents for Chickpea (Cicer Arietinum L.): Leads from QSAR Analysis of Ethyl Oxanilates and Pyridones", J. AGRIC. FOOD CHEM., vol. 54, no. 5, 2 February 2006 (2006-02-02), pages 1868 - 1873, XP055347953, ISSN: 0021-8561
ZHOU, W. ET AL.: "CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero) Aryl Chlorides and Amines", J. AM. CHEM. SOC., vol. 137, no. 37, 9 September 2015 (2015-09-09), pages 11942 - 11945, XP055347955, ISSN: 2394-5311
FAN, M.Y. ET AL.: "Assembly of Primary (Hetero) Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia", ORG. LETT, vol. 17, no. 23, 24 November 2015 (2015-11-24), pages 5934 - 5937, XP055347956, ISSN: 1523-7052
FAN, M.Y. ET AL.: "CuI/Oxalamide Catalyzed Couplings of (Hetero)aryl Chlorides and Phenols for Diaryl Ether Formation", ANGEW. CHEM. INT. ED., vol. 55, no. 21, 13 April 2016 (2016-04-13), pages 6211 - 6215, XP055347957, ISSN: 1521-3773
ZHANG, Y. ET AL.: "CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines", ORGANIC LETTERS, vol. 14, no. 12, 4 June 2012 (2012-06-04), pages 3056 - 3059, XP055347958, ISSN: 1523-7052
See also references of EP 3326715A4
KAJAL, C. ET AL.: "Chemical Hybridizing Agents for Chickpea (Cicer Arietinum L.): Leads from QSAR Analysis of Ethyl Oxanilates and Pyridones", J. AGRIC. FOOD CHEM., vol. 54, no. 5, 2 February 2006 (2006-02-02), pages 1868 - 1873, XP055347953, ISSN: 0021-8561
ZHOU, W. ET AL.: "CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero) Aryl Chlorides and Amines", J. AM. CHEM. SOC., vol. 137, no. 37, 9 September 2015 (2015-09-09), pages 11942 - 11945, XP055347955, ISSN: 2394-5311
FAN, M.Y. ET AL.: "Assembly of Primary (Hetero) Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia", ORG. LETT, vol. 17, no. 23, 24 November 2015 (2015-11-24), pages 5934 - 5937, XP055347956, ISSN: 1523-7052
FAN, M.Y. ET AL.: "CuI/Oxalamide Catalyzed Couplings of (Hetero)aryl Chlorides and Phenols for Diaryl Ether Formation", ANGEW. CHEM. INT. ED., vol. 55, no. 21, 13 April 2016 (2016-04-13), pages 6211 - 6215, XP055347957, ISSN: 1521-3773
ZHANG, Y. ET AL.: "CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines", ORGANIC LETTERS, vol. 14, no. 12, 4 June 2012 (2012-06-04), pages 3056 - 3059, XP055347958, ISSN: 1523-7052
See also references of EP 3326715A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: