Title:
OXIDIZED LDL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2013/118839
Kind Code:
A1
Abstract:
The present invention provides an oxidized LDL inhibitor which (i) binds specifically to oxidized LDL, (ii) suppresses physiological activity of oxidized LDL, and (iii) is able to inhibit uptake of oxidized LDL into cells. This oxidized LDL inhibitor contains Del-1 protein as an active ingredient. The Del-1 protein comprises, for example, an amino acid sequence indicated by SEQ ID NO: 1.
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Inventors:
SAWAMURA TATSUYA (JP)
KAKINO AKEMI (JP)
KAKINO AKEMI (JP)
Application Number:
PCT/JP2013/052939
Publication Date:
August 15, 2013
Filing Date:
February 07, 2013
Export Citation:
Assignee:
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
International Classes:
A61K38/00; A61P9/10; A61P43/00
Domestic Patent References:
| WO2011025050A1 | 2011-03-03 | |||
| WO2006042197A2 | 2006-04-20 | |||
| WO2005001093A1 | 2005-01-06 | |||
| WO2010150538A1 | 2010-12-29 | |||
| WO2010147171A1 | 2010-12-23 |
Foreign References:
| JP2005023032A | 2005-01-27 | |||
| JP2007297381A | 2007-11-15 | |||
| JP2007320956A | 2007-12-13 | |||
| JP2011006326A | 2011-01-13 |
Other References:
A. KAKINO ET AL.: "Identification of Del-1 as an endogenous oxidized LDL inhibitor", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 118, no. SUPPL., 15 February 2012 (2012-02-15), pages 77P, 01C1 - 5-2, XP008173811
RIKINARI HANAYAMA, MASATO TANAKA, KEIKO MIWA, SHIGEKAZU NAGATA: "EXPRESSION OF DEVELOPMENTAL ENDOTHELIAL LOCUS-1 IN A SUBSET OF MACROPHAGES FOR ENGULFMENT OF APOPTOTIC CELLS", JOURNAL OF IMMUNOLOGY, vol. 172, no. 6, 2004, pages 3876 - 3882, XP002389680
CHOI EY ET AL.: "Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment", SCIENCE, vol. 322, no. 5904, 2008, pages 1101 - 1104, XP055165830, DOI: doi:10.1126/science.1165218
HANAYAMA R ET AL.: "Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells", THE JOURNAL OF IMMUNOLOGY, vol. 172, no. 6, 2004, pages 3876 - 3882, XP002389680
PENTA K ET AL.: "Dell induces integrin signaling and angiogenesis by ligation of alphaVbeta3", J BIOL. CHEM., vol. 274, no. 16, 1999, pages 11101 - 11109, XP002186838, DOI: doi:10.1074/jbc.274.16.11101
REZAEE M ET AL.: "Dell mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3", AM J PHYSIOL HERT CIRC PHYSIOL, vol. 282, no. 5, 2002, pages 1924 - 1932, XP002405733
SCHEURER SB ET AL.: "Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study", PROTEOMICS, vol. 4, no. 9, 2004, pages 1737 - 1760
STEINBRECHER UP: "Receptors for oxidized low density lipoprotein", BIOCHIM BIOPHYS ACTA, vol. 436, no. 3, 1999, pages 279 - 298, XP004277065, DOI: doi:10.1016/S0005-2760(98)00127-1
"Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury", CIRCULATION RESEARCH, vol. 108, 2011, pages 797 - 807
GORDON ET AL., PROC.NALT.ACAD.SCI., vol. 77, 1980, pages 7380 - 7384
RIKINARI HANAYAMA, MASATO TANAKA, KEIKO MIWA, SHIGEKAZU NAGATA: "EXPRESSION OF DEVELOPMENTAL ENDOTHELIAL LOCUS-1 IN A SUBSET OF MACROPHAGES FOR ENGULFMENT OF APOPTOTIC CELLS", JOURNAL OF IMMUNOLOGY, vol. 172, no. 6, 2004, pages 3876 - 3882, XP002389680
CHOI EY ET AL.: "Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment", SCIENCE, vol. 322, no. 5904, 2008, pages 1101 - 1104, XP055165830, DOI: doi:10.1126/science.1165218
HANAYAMA R ET AL.: "Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells", THE JOURNAL OF IMMUNOLOGY, vol. 172, no. 6, 2004, pages 3876 - 3882, XP002389680
PENTA K ET AL.: "Dell induces integrin signaling and angiogenesis by ligation of alphaVbeta3", J BIOL. CHEM., vol. 274, no. 16, 1999, pages 11101 - 11109, XP002186838, DOI: doi:10.1074/jbc.274.16.11101
REZAEE M ET AL.: "Dell mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3", AM J PHYSIOL HERT CIRC PHYSIOL, vol. 282, no. 5, 2002, pages 1924 - 1932, XP002405733
SCHEURER SB ET AL.: "Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study", PROTEOMICS, vol. 4, no. 9, 2004, pages 1737 - 1760
STEINBRECHER UP: "Receptors for oxidized low density lipoprotein", BIOCHIM BIOPHYS ACTA, vol. 436, no. 3, 1999, pages 279 - 298, XP004277065, DOI: doi:10.1016/S0005-2760(98)00127-1
"Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury", CIRCULATION RESEARCH, vol. 108, 2011, pages 797 - 807
GORDON ET AL., PROC.NALT.ACAD.SCI., vol. 77, 1980, pages 7380 - 7384
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
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