OXO-SUBSTITUTED COMPOUNDS, PROCESS OF MAKING, AND COMPOSITIONS AND METHODS FOR INHIBITING PARP ACTIVITY

Title:

OXO-SUBSTITUTED COMPOUNDS, PROCESS OF MAKING, AND COMPOSITIONS AND METHODS FOR INHIBITING PARP ACTIVITY

Document Type and Number:

WIPO Patent Application WO1999011624

Kind Code:

B1

Abstract:

Compound, compositions containing compounds, methods of using compounds, and processes of making compounds, of formula (I) containing at least one ring nitrogen, or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer or mixtures thereof, wherein: X is double-bonded oxygen, or -OH; when R<7> is present, it is hydrogen or lower alkyl; y represents the atoms necessary to form a fused mono-, bi- or tricyclic, carbocylic or heterocyclic ring, wherein each individual ring has 5-6 ring member atoms; and Z is (i) -CH<2>CHR<3>- wherein R<2> and R<3> are independently hydrogen, alkyl, aryl or aralkyl; (ii) -R<6>C=CR<3>- wherein R<3> and R<6> are independently hydrogen, lower alkyl, aryl, aralkyl, halo, -NO2, -COOR<7>, or -NR<7>R<8> where R<8> is independently hydrogen or C1-C9 alkyl, or R<6> and R<3>, taken together, form a fused aromatic ring, wherein each individual ring has 5-6 ring members; (iii) -R<2>C=N-; (iv) -CR<2>(OH)-NR<7>; or (v) -C(O)-NR<7>-.

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Inventors:

LI JIA-HE
TAYS KEVIN L
ZHANG JIE

Application Number:

PCT/US1998/018195

Publication Date:

April 22, 1999

Filing Date:

September 02, 1998

Export Citation:

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Assignee:

GUILFORD PHARM INC (US)

International Classes:

A61K31/435; A61K31/4355; A61K31/436; A61K31/4365; A61K31/437; A61K31/4375; A61K31/472; A61K31/502; A61K31/5025; A61K31/5365; A61K31/5383; C07D243/14; A61K31/5513; A61K31/553; A61P35/00; A61P43/00; C07D217/22; C07D217/24; C07D217/26; C07D221/04; C07D221/12; C07D221/18; C07D237/30; C07D237/32; C07D237/34; C07D239/88; C07D239/93; C07D239/94; C07D267/14; C07D471/04; C07D471/06; C07D475/02; C07D487/04; C07D491/04; C07D491/048; C07D491/052; C07D495/04; C07D495/14; C07D498/04; C07D498/14; C07D513/04; C07F9/6561; (IPC1-7): C07D221/12; C07D221/16; C07D221/18; A61K31/47; C07D491/04; C07D217/24; C07D237/32; C07D475/02

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