Title:
OXYNITRIDE HETEROCYCLIC HEPTANE-BASED SPIRO COMPOUND, INTERMEDIATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/047616
Kind Code:
A1
Abstract:
Provided are an oxynitride heterocyclic heptane-based spiro compound, an intermediate and a preparation method therefor. The present invention relates to a preparation method for the compound as shown in formula 7a or formula 8a. The preparation method for the compound as shown in formula 7a comprises the following step: in an organic solvent, the compound as shown in formula 6 and a chiral resolving agent X1 are subjected to a salt forming reaction as shown below; and X1 is a chiral resolving agent in R configuration; the preparation method for the compound as shown in formula 8a comprises the following step: in an organic solvent, the compound as shown in formula 6 and a chiral resolving agent X2 are subjected to a salt forming reaction as shown below; and X2 is a chiral resolving agent in S configuration.
Inventors:
WEN JIANFENG (CN)
FENG JIANPENG (CN)
WU QINGQUAN (CN)
WANG CHUANSHEN (CN)
FENG JIANPENG (CN)
WU QINGQUAN (CN)
WANG CHUANSHEN (CN)
Application Number:
PCT/CN2020/114629
Publication Date:
March 18, 2021
Filing Date:
September 11, 2020
Export Citation:
Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
C07D498/08; C07D498/22
Domestic Patent References:
| WO2019173181A1 | 2019-09-12 | |||
| WO2018107060A1 | 2018-06-14 |
Foreign References:
| CN107001387A | 2017-08-01 |
Other References:
DATABASE REGISTRY 4 April 2019 (2019-04-04), ANONYMOUS O M: "Propanedioic acid, 2-[3-(2,4-dimethylphenyl)-2-propen-1-yl]-, 1,3-dimethyl ester (CA INDEX NAME)", XP055790445, retrieved from STN Database accession no. 2301037-18-1
MECIAROVA, M. TOMA, S. LUCHE, J.-L.: "The sonochemical arylation of malonic esters mediated by manganese triacetate", ULRASONICS SONOCHEMISTRY, BUTTERWORTH-HEINEMANN., GB, vol. 8, no. 2, 1 April 2001 (2001-04-01), GB, pages 119 - 122, XP004233287, ISSN: 1350-4177, DOI: 10.1016/S1350-4177(00)00029-8
LASA, M. ; LOPEZ, P. ; CATIVIELA, C.: "Synthesis of the four stereoisomers of cyclobutane analogues of phenylalanine in enantiomerically pure form", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 16, no. 24, 12 December 2005 (2005-12-12), OXFORD, GB, pages 4022 - 4033, XP027676126, ISSN: 0957-4166
MECIAROVA, M. TOMA, S. LUCHE, J.-L.: "The sonochemical arylation of malonic esters mediated by manganese triacetate", ULRASONICS SONOCHEMISTRY, BUTTERWORTH-HEINEMANN., GB, vol. 8, no. 2, 1 April 2001 (2001-04-01), GB, pages 119 - 122, XP004233287, ISSN: 1350-4177, DOI: 10.1016/S1350-4177(00)00029-8
LASA, M. ; LOPEZ, P. ; CATIVIELA, C.: "Synthesis of the four stereoisomers of cyclobutane analogues of phenylalanine in enantiomerically pure form", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 16, no. 24, 12 December 2005 (2005-12-12), OXFORD, GB, pages 4022 - 4033, XP027676126, ISSN: 0957-4166
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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