Title:
P2X4 RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2015/005467
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by general formula (I) having a P2X4 receptor antagonist action.
(I)
(In the formula, R1, R2 and R3 are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, etc., X is C or N, and Y is N or C (=O), provided that when X is C, Y is N, and when X is N, Y is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, n is an integer of 0 to 6, Z is O, S or a bond, and A is a benzene ring, a pyridine ring, etc.)
Inventors:
SAKUMA SHOGO (JP)
KOBAYASHI KUNIO (JP)
USHIODA MASATOSHI (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
KOBAYASHI KUNIO (JP)
USHIODA MASATOSHI (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
Application Number:
PCT/JP2014/068540
Publication Date:
January 15, 2015
Filing Date:
July 11, 2014
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
UNIV KYUSHU (JP)
UNIV KYUSHU (JP)
International Classes:
C07D243/10; A61K31/551; A61P25/04; A61P29/00; A61P43/00; C07D401/12
Domestic Patent References:
| WO2012014910A1 | 2012-02-02 | |||
| WO2010093061A1 | 2010-08-19 | |||
| WO2012011549A1 | 2012-01-26 | |||
| WO2012060397A1 | 2012-05-10 | |||
| WO2012161301A1 | 2012-11-29 | |||
| WO2004085440A1 | 2004-10-07 | |||
| WO2008023847A1 | 2008-02-28 | |||
| WO2010093061A1 | 2010-08-19 | |||
| WO2010090300A1 | 2010-08-12 | |||
| WO2012008478A1 | 2012-01-19 | |||
| WO2012011549A1 | 2012-01-26 | |||
| WO2012014910A1 | 2012-02-02 | |||
| WO2012017876A1 | 2012-02-09 | |||
| WO2013105608A1 | 2013-07-18 | |||
| WO2008023847A1 | 2008-02-28 |
Foreign References:
| US20050074819A1 | 2005-04-07 |
Other References:
BUELL ET AL., EMBO J., vol. 15, 1996, pages 55 - 62
SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
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WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
M. TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.; M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
"Abstract P3-N-114", THE 49TH CONVENTION OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, 2006
KIM, S.H.; CHUNG, J.M. ET AL.: "An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat", PAIN, vol. 50, 1992, pages 355 - 363
CHAPLAN SR; BACH FW; POGREL JW; CHUNG JM; YAKSH TL: "Quantitative assessment of tactile allodynia in the rat paw", J. NEUROSCI. METHOD, vol. 53, 1994, pages 55 - 63
SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
SOTO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 3684 - 3788
WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
M. TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.; M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
"Abstract P3-N-114", THE 49TH CONVENTION OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, 2006
KIM, S.H.; CHUNG, J.M. ET AL.: "An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat", PAIN, vol. 50, 1992, pages 355 - 363
CHAPLAN SR; BACH FW; POGREL JW; CHUNG JM; YAKSH TL: "Quantitative assessment of tactile allodynia in the rat paw", J. NEUROSCI. METHOD, vol. 53, 1994, pages 55 - 63
Attorney, Agent or Firm:
CHIGUSA, Shinichi et al. (JP)
1000 Shin-ichi Kusa (JP)
1000 Shin-ichi Kusa (JP)
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