Title:
PHARMACEUTICAL COMPOSITIONS FOR THE COORDINATED DELIVERY OF NSAIDs
Document Type and Number:
WIPO Patent Application WO2002098352
Kind Code:
A3
Abstract:
The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of trating patients by administering this coordinated release, gastroprotective, antiarthitic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.
Inventors:
PLACHETKA JOHN R
Application Number:
PCT/US2002/017105
Publication Date:
June 26, 2003
Filing Date:
May 31, 2002
Export Citation:
Assignee:
POZEN INC (US)
International Classes:
A61K9/22; A61K9/24; A61K9/26; A61K9/28; A61K9/32; A61K9/36; A61K9/48; A61K9/50; A61K9/20; A61K9/52; A61K9/58; A61K9/62; A61K31/167; A61K31/192; A61K31/341; A61K31/405; A61K31/415; A61K31/4164; A61K31/42; A61K31/421; A61K31/426; A61K31/4439; A61K31/444; A61K31/4453; A61K31/5415; A61K31/616; A61K45/06; A61P1/04; A61P19/02; A61P29/00; A61P43/00; (IPC1-7): A61K9/22; A61K9/24; A61K9/26; A61K9/32; A61K9/36; A61K9/52; A61K9/58; A61K9/62
Foreign References:
| US5716648A | 1998-02-10 |
Other References:
See also references of EP 1411900A4
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