Title:
PROCESS FOR PRODUCING $g(b)-LACTAM DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/058931
Kind Code:
A1
Abstract:
A process for producing $g(b)-lactam derivatives, characterized by treating a $g(b)-lactam derivative having a protected carboxyl group and represented by the general formula (1): A-COO-X (wherein A is a $g(b)-lactam derivative residue; and X is a benzyl group which may have an electron-donating group as a substituent on the phenyl ring, or a diphenylmethyl group which may have an electron-donating group on the phenyl ring) with an aluminum halide in an aliphatic ether solvent to obtain a $g(b)-lactam derivative of the general formula (2): A-COOH (wherein A is as defined above), whereby the leaving group X can be recovered as X-OH and reused.
Inventors:
KAMEYAMA YUTAKA (JP)
Application Number:
PCT/JP1998/002630
Publication Date:
December 30, 1998
Filing Date:
June 16, 1998
Export Citation:
Assignee:
OTSUKA KAGAKU KK (JP)
KAMEYAMA YUTAKA (JP)
KAMEYAMA YUTAKA (JP)
International Classes:
A61K31/43; A61K31/545; A61K31/546; A61P31/04; C07D463/00; C07D463/06; C07D471/04; C07D495/04; C07D499/00; C07D499/08; C07D499/46; C07D501/00; C07D501/04; C07D501/26; C07D501/36; C07D501/57; C07D501/59; C07D503/00; C07D505/00; (IPC1-7): C07D501/04; C07D463/06; C07D498/04; C07D499/00; C07D499/08
Foreign References:
| JPS61263984A | 1986-11-21 | |||
| JPS61118329A | 1986-06-05 | |||
| JPS61293987A | 1986-12-24 |
Other References:
See also references of EP 1000945A4
Attorney, Agent or Firm:
Tamura, Iwao (4-5-103 Terauchi 1-chom, Toyonaka-shi Osaka-fu, JP)
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