PROCESS FOR THE SELECTIVE PREPARATION OF Z-ISOMERS OF 3-(2-SUBSTITUTED VINYL)CEPHALOSPORINS

Title:

PROCESS FOR THE SELECTIVE PREPARATION OF Z-ISOMERS OF 3-(2-SUBSTITUTED VINYL)CEPHALOSPORINS

Document Type and Number:

WIPO Patent Application WO/1998/058932

Kind Code:

A1

Abstract:

Z-Isomers of compounds of general formula (IV): [wherein R?1¿ is 2-(2-N-protected aminothiazol-4-yl)-2-alkoxyiminoacetyl or the like, R?2¿ is hydrogen or the like; R?3¿ is hydrogen, a carboxyl-protecting group or the like; and R?8¿ is alkyl or the like] can be prepared at high selectivities and in high yields by reacting a compound of general formula (I): [wherein R?1¿, R?2¿ and R?3¿ are each as defined above; and R?4¿ is aryl or the like] with a 4-substituted or -unsubstituted thiazole-5-carbaldehyde in a mixed solvent comprising a chlorinated hydrocarbon and a lower alkanol at a temperature of as low as +5 °C or below.

Inventors:

OKADA YUMIKO (JP)
SUKEGAWA MASAMICHI (JP)
WATANABE TATSUO (JP)
IWASAWA HIROYUKI (JP)
MURAI YASUSHI (JP)
IINUMA KATSUHARU (JP)

Application Number:

PCT/JP1998/002820

Publication Date:

December 30, 1998

Filing Date:

June 24, 1998

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MEIJI SEIKA KAISHA (JP)
OKADA YUMIKO (JP)
SUKEGAWA MASAMICHI (JP)
WATANABE TATSUO (JP)
IWASAWA HIROYUKI (JP)
MURAI YASUSHI (JP)
IINUMA KATSUHARU (JP)

International Classes:

A61K31/545; C07D501/00; C07D501/04; C07D501/12; C07D501/24; (IPC1-7): C07D501/04; C07D501/12; C07D501/24; C07M9/00

Foreign References:

JPH07188250A	1995-07-25
JPS6219593A	1987-01-28
JPH03128382A	1991-05-31
JPH0867684A	1996-03-12

Other References: