Title:
PAN-KRAS DEGRADING AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/083256
Kind Code:
A1
Abstract:
Provided in the present invention are a pan-KRAS degrading agent, and a preparation method therefor and the use thereof. Specifically, disclosed in the present invention are a small molecule compound for targeted degradation of the pan-KRAS protein, and a preparation method therefor and the use thereof as a therapeutic agent for preventing and/or treating cancers. The compound of the present invention can effectively degrade and/or inhibit the pan-KRAS protein in cells, and can be used in the preparation of a drug for treating and/or preventing relevant diseases or conditions mediated by pan-KRAS.
Inventors:
YE ZHENGQING (CN)
FENG YAN (CN)
DING CHENLI (CN)
FENG YAN (CN)
DING CHENLI (CN)
Application Number:
PCT/CN2023/125974
Publication Date:
April 25, 2024
Filing Date:
October 23, 2023
Export Citation:
Assignee:
SHANGHAI LEADINGTAC PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/517; A61K31/519; A61P35/00; C07D239/94; C07D239/95; C07D519/00
Domestic Patent References:
WO2021207172A1 | 2021-10-14 | |||
WO2022111521A1 | 2022-06-02 | |||
WO2022266206A1 | 2022-12-22 | |||
WO2023077441A1 | 2023-05-11 |
Foreign References:
CN112218859A | 2021-01-12 | |||
CN116375742A | 2023-07-04 | |||
CN116891514A | 2023-10-17 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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