PANCREATIC CANCER ASSOCIATED ANTIGEN, ANTIBODY THERETO, AND DIAGNOSTIC AND TREATMENT METHODS

Title:

PANCREATIC CANCER ASSOCIATED ANTIGEN, ANTIBODY THERETO, AND DIAGNOSTIC AND TREATMENT METHODS

Document Type and Number:

WIPO Patent Application WO2004065547

Kind Code:

A3

Abstract:

The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Agl, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Agl exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.

Inventors:

MICHL JOSEF (US)
BRADU STEFAN M (US)
HANNAN RAQUIB (US)
PINCUS MATTHEW R (US)

Application Number:

PCT/US2004/001196

Publication Date:

June 02, 2005

Filing Date:

January 16, 2004

Export Citation:

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Assignee:

UNIV NEW YORK STATE RES FOUND (US)
MICHL JOSEF (US)
BRADU STEFAN M (US)
HANNAN RAQUIB (US)
PINCUS MATTHEW R (US)

International Classes:

A61K38/00; A61K39/00; A61K39/02; A61K39/38; A61K47/48; A61K51/10; C07K1/00; C07K2/00; C07K4/00; C07K5/00; C07K14/00; C07K14/47; C07K16/00; C07K16/30; C07K17/00; C12N1/00; C12N; (IPC1-7): A61K39/00; A61K39/38; A61K39/02; A61K38/00; C07K1/00; C07K2/00; C07K4/00; C07K5/00; C07K14/00; C07K16/00; C07K17/00

Domestic Patent References:

WO2004065547A2

2004-08-05

Other References: