Title:
PENTACYCLIC TRITERPENE SAPONIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/065907
Kind Code:
A1
Abstract:
Provided are a pentacyclic triterpene saponin derivative, a preparation method therefor, and a use thereof. A compound A3 is used as a raw material, a derivative is prepared by targeting a carboxyl group of C-28 and using an esterification reaction or amidation reaction, and said derivative is used as an active ingredient to prepare drugs having anti-inflammatory, antioxidant and anti-apoptotic effects. The pentacyclic triterpene saponin derivative does not show obvious cytotoxicity to macrophages, has better anti-inflammatory activity, and can alleviate the symptoms of colitis in mice. In addition, said derivative antagonizes the cytotoxicity of cisplatin and can significantly inhibit the release of reactive oxygen species (ROS) in renal cells caused by cisplatin.
Inventors:
LIU YANLI (CN)
XU QIONGMING (CN)
LV LIJUAN (CN)
WANG KEXIN (CN)
XU QIONGMING (CN)
LV LIJUAN (CN)
WANG KEXIN (CN)
Application Number:
PCT/CN2022/126911
Publication Date:
April 04, 2024
Filing Date:
October 24, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07J63/00; A61K31/704; A61P29/00; A61P35/00; A61P39/06
Foreign References:
| CN102164942A | 2011-08-24 | |||
| CN101730706A | 2010-06-09 | |||
| CN105213410A | 2016-01-06 |
Other References:
ZHA, ZHENGXIA ET AL.: "Research Progress on Pharmacological Activities of Triterpenoid Saponins from Pulsatilla chinensis (Bunge) Regel", TRADITIONAL CHINESE DRUG RESEARCH AND CLINICAL PHARMACOLOGY, vol. 31, no. 1, 31 January 2020 (2020-01-31)
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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