PEPTIDE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF

WIPO Patent Application WO/2003/042237

A1

A peptide derivative represented by the general formula (I): (I) wherein X represents −CH(OH)− or −CO−&semi R¹ represents hydrogen or an amino−protecting group&semi R² represents hydroxy or lower alkoxy&semi one of R³ and R⁴ represents an R group side chain of lysine in which each amino group may be protected with a protective group and the other represents an R group side chain of arginine in which the quanidino group may be protected with a protective group&semi and R⁵ and R⁶ are the same or different and each represents hydrogen, lower alkyl, or aralkyl.

YAMAMOTO KENJI (JP)
SUDA YOSHIMITSU (JP)
ASAO TETSUJI (JP)

PCT/JP2002/011860

May 22, 2003

November 14, 2002

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TAIHO PHARMACEUTICAL CO LTD (JP)
YAMAMOTO KENJI (JP)
SUDA YOSHIMITSU (JP)
ASAO TETSUJI (JP)

A61P1/02; C07C279/36; C07K5/02; A61K38/00; (IPC1-7): C07K5/023; C12N9/99; A61K38/55; A61P1/02

WO2002036551A1

2002-05-10

JPH11228526A

1999-08-24

PIKE R. ET AL.: "Lysine- and arginine-specific proteinases from porphyromonas gingivalis", J. BIOL. CHEM., vol. 269, no. 1, 1994, pages 406 - 411, XP000606021
TAKAYO BABA ET AL.: "Tokushu protease to shikkan, shishubyo kenkyu no saizensen -shishu byogen saikin to shishu byogensei inshi wa dokomade akirakani saretaka", THE TISSUE CULTURE ENGINEERING, vol. 27, no. 9, August 2001 (2001-08-01), pages 343 - 347, XP002964383
See also references of EP 1445262A4

Saegusa, Eiji (1-7-1 Doshomachi, Chuo-k, Osaka-shi Osaka, JP)

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