PEPTIDE DERIVATIVES AND THEIR USE

Title:

PEPTIDE DERIVATIVES AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/1990/002751

Kind Code:

A1

Abstract:

The invention provides peptide derivatives comprising synthetic cyclic peptides represented by formula (I), or salts thereof, wherein R represents an amino acid residue or an oligo- or polypeptide residue, and a pharmaceutical agent containing said derivative as an active ingredient and inhibiting adhesion of animal cells to a substrate. The peptide derivatives are stable to hydrolysis by enzymes, and the pharmaceutical agent is effective in inhibiting adhesion of animal cells to a substrate, depressing metastasis of cancer cells, and inhibiting agglutination of platelets.

Inventors:

OHBA MASATAKA (JP)
KUMAGAI HIROMICHI (JP)
HARIE SHUNSAKU (JP)
UCHIDA KEIICHI (JP)

Application Number:

PCT/JP1989/000926

Publication Date:

March 22, 1990

Filing Date:

September 08, 1989

Export Citation:

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Assignee:

ASAHI GLASS CO LTD (JP)

International Classes:

A61K38/00; A61K31/00; A61P7/02; A61P35/00; A61P43/00; C07K5/12; C07K7/64; C07K14/75; C07K14/78; (IPC1-7): C07K5/12; A61K37/02; C07K7/64; C12N5/00

Domestic Patent References:

WO1988003560A1

1988-05-19

Other References: