PEPTIDE AND METHOD OF OBTAINING IT - DEIGIN VLADISLAV ISAKOVICH

Title:

PEPTIDE AND METHOD OF OBTAINING IT

Document Type and Number:

WIPO Patent Application WO/1996/040740

Kind Code:

A1

Abstract:

The invention pertains to medicine, specifically to methods of obtaining biologically active substances with immunoregulatory properties, and can be used in medicine, veterinary science and experimental biochemistry. The problem addressed by the invention is that of producing a novel synthetic biologically active peptide with immunoregulatory properties of formula X-A-D-Trp-Y, in which A is D-Glu, iD-GLu; X is H or Gly, Ala, Leu, Ile, Val, Nval, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, 'gamma'-aminobutyric acid, 'xi'-aminocaproic acid; Y is Gly, Ala, Leu, Ile, Val, Nval, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, 'gamma'-aminobutyric acid, 'xi'-aminocaproic acid, -OH or substituted amide (C1-C3). The method of producing the peptide involves the synthesis of glutamil-containing peptides in solution by scission of an internal anhydride of tributyloxycarbonyl glutamic (D or L) acid with the appropriate k-salt of D-Trp-Y. This is followed by chromatographic separation of the 'alpha'- and 'gamma' isomers. Further synthesis was carried out by building up a peptide chain using activated esters of tributyloxycarbonylamino acids.

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Inventors:

DEIGIN VLADISLAV ISAKOVICH (RU)
KOROTKOV ANDREI MARXOVICH (RU)

Application Number:

PCT/RU1996/000116

Publication Date:

December 19, 1996

Filing Date:

May 06, 1996

Export Citation:

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Assignee:

DEIGIN VLADISLAV ISAKOVICH (RU)
KOROTKOV ANDREI MARXOVICH (RU)

International Classes:

A61K31/00; A61K38/07; A61K38/08; A61P37/00; A61P37/02; C07K1/02; C07K1/06; A61K38/00; C07K1/16; C07K5/02; C07K5/065; C07K5/08; C07K5/083; C07K5/087; C07K5/093; C07K5/097; C07K5/103; C07K5/107; (IPC1-7): C07K5/06; C07K5/08; C07K5/10; A61K38/05; A61K38/06; A61K38/07

Domestic Patent References:

WO1989006134A1

1989-07-13

Foreign References:

US3832337A	1974-08-27
EP0101929A1	1984-03-07
GB1526367A	1978-09-27
GB2109796A	1983-06-08

Other References: