Title:
PEPTIDES ANTAGONISTIC TO AN ANTI-ANGIOGENIC ANTIBODY AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO2005000871
Kind Code:
A3
Abstract:
The invention concerns antagonists of alphaV-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.
Inventors:
SHEALY DAVID (US)
WU SAM (US)
CHEN YAN (US)
BAKER AUDREY (US)
WU SAM (US)
CHEN YAN (US)
BAKER AUDREY (US)
Application Number:
PCT/US2004/019898
Publication Date:
July 14, 2005
Filing Date:
June 22, 2004
Export Citation:
Assignee:
CENTOCOR INC (US)
SHEALY DAVID (US)
WU SAM (US)
CHEN YAN (US)
BAKER AUDREY (US)
SHEALY DAVID (US)
WU SAM (US)
CHEN YAN (US)
BAKER AUDREY (US)
International Classes:
A61K38/04; A61K39/395; C07K7/06; C07K7/08; C07K14/705; C07K16/28; C07K16/46; C12P21/04; C12Q1/68; C07K; (IPC1-7): A61K38/04; A61K39/395; C07K16/46; C12Q1/68
Other References:
BIRKENMEIER ET AL.: "Epitope mapping by screening of phage display librries of a monoclonal antibody directed against the receptor binding domain of human alpha2-macroglobulin", FEBS LETT., vol. 416, no. 2, 20 October 1997 (1997-10-20), pages 193 - 196, XP004261339
BYUN ET AL.: "Identificatoin of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from phage-displayed peptide library", J. CLIN. ENDOCRINOL. METAB., vol. 86, no. 7, 2001, pages 3311 - 3318, XP002251044
AL-BUKHARI ET AL.: "An immuno-precipitation assay for determining specific interactions between antibodies and phage selected from random peptide expression libraries", J. IMMUNOL. METHODS, vol. 264, no. 1-2, 1 June 2002 (2002-06-01), pages 163 - 171, XP004362078
BYUN ET AL.: "Identificatoin of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from phage-displayed peptide library", J. CLIN. ENDOCRINOL. METAB., vol. 86, no. 7, 2001, pages 3311 - 3318, XP002251044
AL-BUKHARI ET AL.: "An immuno-precipitation assay for determining specific interactions between antibodies and phage selected from random peptide expression libraries", J. IMMUNOL. METHODS, vol. 264, no. 1-2, 1 June 2002 (2002-06-01), pages 163 - 171, XP004362078
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