Title:
PHARMACEUTICAL COMPOSITION COMPRISING THA AS ACTIVE INGREDIENT FOR TREATING BREAST CANCER
Document Type and Number:
WIPO Patent Application WO/2018/074862
Kind Code:
A3
Abstract:
The present invention relates to a composition comprising 2,4,6-trihydroxyacetophenone (THA) as an active ingredient for preventing, alleviating, or treating breast cancer. More specifically, the composition of the present invention exhibits an excellent effect in the treatment of breast cancer by inhibiting the activity of polo-like kinase 1 (Plk1), and thus is expected to be used to prevent, alleviate, and treat breast cancer.
Inventors:
KANG KEON WOOK (KR)
OH KWANG-SEOK (KR)
KIM YOUNGCHUL (KR)
JEONG SUNG BAEK (KR)
OH KWANG-SEOK (KR)
KIM YOUNGCHUL (KR)
JEONG SUNG BAEK (KR)
Application Number:
PCT/KR2017/011595
Publication Date:
August 09, 2018
Filing Date:
October 19, 2017
Export Citation:
Assignee:
KOREA UNITED PHARM INC (KR)
International Classes:
A61K36/9066; A23L33/105; A61K31/12
Foreign References:
| US20060074108A1 | 2006-04-06 |
Other References:
CHO, M.-Y.: "Apoptosis-inducing Activity of Synthetic Polyphenol Compound, 3-geranyl-2,4,6-trihydroxyacetophenone, in MCF-7 and Adriamycin-resistant MCF-7 Breast Cancer Cells", THESIS, 2009
CHO, M.-Y. ET AL.: "Geranyl Derivative of Phloroacetophenone Induces Cancer Cell -specific Apoptosis through Bax-mediated Mitochondrial Pathway in MCF-7 Human Breast Cancer Cells", BIOLOGICAL AND PHARMACEUTICAL BULLETI N, vol. 35, no. 1, 2012, pages 98 - 104, XP055535531
FERREIRA, E. A. ET AL.: "The 2',4',6'-trihydroxyacetophenone Isolated from Myrcia Multiflora Has Antiobesity and Mixed Hypolipidemic Effects with the Reduction of Lipid Intestinal Absorption", PLANTA MEDICA, vol. 77, no. 14, 2011, pages 1569 - 1574, XP055535535
REZK, B. M. ET AL.: "The Antioxidant Activity of Phloretin: the Disclosure of a New Antioxidant Pharmacophore in Flavonoids", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 295, no. 1, 2002, pages 9 - 13, XP055535541
CHO, M.-Y. ET AL.: "Geranyl Derivative of Phloroacetophenone Induces Cancer Cell -specific Apoptosis through Bax-mediated Mitochondrial Pathway in MCF-7 Human Breast Cancer Cells", BIOLOGICAL AND PHARMACEUTICAL BULLETI N, vol. 35, no. 1, 2012, pages 98 - 104, XP055535531
FERREIRA, E. A. ET AL.: "The 2',4',6'-trihydroxyacetophenone Isolated from Myrcia Multiflora Has Antiobesity and Mixed Hypolipidemic Effects with the Reduction of Lipid Intestinal Absorption", PLANTA MEDICA, vol. 77, no. 14, 2011, pages 1569 - 1574, XP055535535
REZK, B. M. ET AL.: "The Antioxidant Activity of Phloretin: the Disclosure of a New Antioxidant Pharmacophore in Flavonoids", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 295, no. 1, 2002, pages 9 - 13, XP055535541
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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