Title:
PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/062134
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for prophylaxis and treatment of NAFLD comprising as an active ingredient a 1,4-benzoxazine compound represented by formula (I): or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, as well as a method for prophylaxis and treatment of NAFLD which comprises administering a therapeutically effective amount of the above-mentioned 1,4-benzoxazine compound represented by formula (I) and so on to a patient in need thereof.
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Inventors:
COOREMAN MICHAEL P (US)
KIKKAWA KOHEI (JP)
KIKKAWA KOHEI (JP)
Application Number:
PCT/JP2017/034654
Publication Date:
April 05, 2018
Filing Date:
September 26, 2017
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
A61K31/538; A61K45/06; A61P1/16
Domestic Patent References:
| WO2007089034A1 | 2007-08-09 | |||
| WO2007089034A1 | 2007-08-09 | |||
| WO2014024950A1 | 2014-02-13 |
Foreign References:
| EP2883870A1 | 2015-06-17 |
Other References:
MARGARITA PIZARRO ET AL: "Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis", LIVER INTERNATIONAL, vol. 35, no. 9, 23 February 2015 (2015-02-23), GB, pages 2129 - 2138, XP055431495, ISSN: 1478-3223, DOI: 10.1111/liv.12794
DAVID W. PIOTROWSKI: "Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic Nephropathy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 18, 27 September 2012 (2012-09-27), pages 7957 - 7966, XP055213613, ISSN: 0022-2623, DOI: 10.1021/jm300806c
D. A. SASS, DIGESTIVE DISEASES AND SCIENCES, vol. 50, no. 1, 2005, pages 171 - 180
J. K. DYSON, FRONTLINE GASTROENTEROLOGY, vol. 0, 2014, pages 1 - 10
J. D. BROWNING, HEPATOLOGY, vol. 40, 2004, pages 1387 - 1395
S. CHITTURI, J. GASTROENTEROL. HEPATOL., vol. 19, 2004, pages 368 - 374
C. D. WILLIAMS, GASTROENTEROLOGY, vol. 140, 2011, pages 124 - 131
Y. EGUCHI, JOURNAL OF GASTROENTEROLOGY, vol. 47, 2012, pages 586 - 595
C. DAY: "The International Liver Congress", EASL POSTGRADUATE COURSE METABOLIC LIVER DISEASE, 2015, pages 93 - 98
B. A. NEUSCHWANDER, THE LANCET, vol. 35, 2015, pages 956 - 965
S. YOKOHAMA, HAPATOLOGY, vol. 40, no. 5, 2004, pages 1222 - 1225
Y. TAMAKI, J. GASTROENTEROLOGY, vol. 48, 2013, pages 491 - 503
R. NOGUCHI, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 26, 2010, pages 407 - 413
"Drug Metabolism - Basis for Clinical Pharmacy and Drug Development"
L. ADORINI, DRUG DISCOVERY TODAY, vol. 17, 2012, pages 988 - 997
M, THOMAS, MOL PHARMACOL, vol. 83, 2013, pages 709 - 718
DAVID W. PIOTROWSKI: "Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic Nephropathy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 18, 27 September 2012 (2012-09-27), pages 7957 - 7966, XP055213613, ISSN: 0022-2623, DOI: 10.1021/jm300806c
D. A. SASS, DIGESTIVE DISEASES AND SCIENCES, vol. 50, no. 1, 2005, pages 171 - 180
J. K. DYSON, FRONTLINE GASTROENTEROLOGY, vol. 0, 2014, pages 1 - 10
J. D. BROWNING, HEPATOLOGY, vol. 40, 2004, pages 1387 - 1395
S. CHITTURI, J. GASTROENTEROL. HEPATOL., vol. 19, 2004, pages 368 - 374
C. D. WILLIAMS, GASTROENTEROLOGY, vol. 140, 2011, pages 124 - 131
Y. EGUCHI, JOURNAL OF GASTROENTEROLOGY, vol. 47, 2012, pages 586 - 595
C. DAY: "The International Liver Congress", EASL POSTGRADUATE COURSE METABOLIC LIVER DISEASE, 2015, pages 93 - 98
B. A. NEUSCHWANDER, THE LANCET, vol. 35, 2015, pages 956 - 965
S. YOKOHAMA, HAPATOLOGY, vol. 40, no. 5, 2004, pages 1222 - 1225
Y. TAMAKI, J. GASTROENTEROLOGY, vol. 48, 2013, pages 491 - 503
R. NOGUCHI, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 26, 2010, pages 407 - 413
"Drug Metabolism - Basis for Clinical Pharmacy and Drug Development"
L. ADORINI, DRUG DISCOVERY TODAY, vol. 17, 2012, pages 988 - 997
M, THOMAS, MOL PHARMACOL, vol. 83, 2013, pages 709 - 718
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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