Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING VASCULAR DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2024/048900
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating vascular dementia comprising glia-like cells differentiated from human mesenchymal stem cells (hMSC). The pharmaceutical composition of the present invention may preferably be used as a therapeutic agent for preventing or treating vascular dementia by inducing regeneration of brain cells or glial cells or inhibiting further damage.
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Inventors:
CHANG MI SOOK (KR)
KOH SEONG HO (KR)
LEE EUN JI (KR)
KOH SEONG HO (KR)
LEE EUN JI (KR)
Application Number:
PCT/KR2023/006022
Publication Date:
March 07, 2024
Filing Date:
May 03, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV HANYANG IND UNIV COOP FOUND (KR)
UNIV HANYANG IND UNIV COOP FOUND (KR)
International Classes:
A61K35/28; A61K35/30; A61P25/28; C12N5/079
Domestic Patent References:
| WO2021034164A1 | 2021-02-25 |
Foreign References:
| KR20210023781A | 2021-03-04 |
Other References:
LLORENTE IRENE L., XIE YUAN, MAZZITELLI JOSE A., HATANAKA EMILY A., CINKORNPUMIN JESSICA, MILLER DAVID R., LIN YING, LOWRY WILLIAM: "Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents", SCIENCE TRANSLATIONAL MEDICINE, vol. 13, no. 590, 21 April 2021 (2021-04-21), XP093143843, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aaz6747
SON JEONG-WOO; PARK JIHYE; KIM YE EUN; HA JIEUN; PARK DONG WOO; CHANG MI-SOOK; KOH SEONG-HO: "Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4", MOLECULAR NEUROBIOLOGY, SPRINGER US, NEW YORK, vol. 56, no. 11, 12 May 2019 (2019-05-12), New York, pages 7617 - 7630, XP036919809, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1629-8
WANG FEI, ZHANG CHI, HOU SIYUAN, GENG XIN: "Synergistic Effects of Mesenchymal Stem Cell Transplantation and Repetitive Transcranial Magnetic Stimulation on Promoting Autophagy and Synaptic Plasticity in Vascular Dementia", JOURNALS OF GERONTOLOGY, SERIES A, BIOLOGICAL SCIENCES ANDMEDICAL SCIENCES, OXFORD UNIV. PRESS, US, vol. 74, no. 9, 16 August 2019 (2019-08-16), US , pages 1341 - 1350, XP093145599, ISSN: 1079-5006, DOI: 10.1093/gerona/gly221
SON JEONG-WOO; PARK JIHYE; KIM YE EUN; HA JIEUN; PARK DONG WOO; CHANG MI-SOOK; KOH SEONG-HO: "Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4", MOLECULAR NEUROBIOLOGY, SPRINGER US, NEW YORK, vol. 56, no. 11, 12 May 2019 (2019-05-12), New York, pages 7617 - 7630, XP036919809, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1629-8
WANG FEI, ZHANG CHI, HOU SIYUAN, GENG XIN: "Synergistic Effects of Mesenchymal Stem Cell Transplantation and Repetitive Transcranial Magnetic Stimulation on Promoting Autophagy and Synaptic Plasticity in Vascular Dementia", JOURNALS OF GERONTOLOGY, SERIES A, BIOLOGICAL SCIENCES ANDMEDICAL SCIENCES, OXFORD UNIV. PRESS, US, vol. 74, no. 9, 16 August 2019 (2019-08-16), US , pages 1341 - 1350, XP093145599, ISSN: 1079-5006, DOI: 10.1093/gerona/gly221
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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