Title:
PHARMACEUTICAL COMPOSITION FOR ALLEVIATING OR TREATING SEQUELAE OF CEREBRAL INFARCTION
Document Type and Number:
WIPO Patent Application WO/2024/048899
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for alleviating or treating sequelae of cerebral infarction, comprising glia-like cells differentiated from a human mesenchymal stem cell (hMSC). The pharmaceutical composition of the present invention can preferably be used as a treatment for alleviating or treating one or more sequelae of cerebral infarction selected from the group including paralysis, swallowing disorder, cognitive impairment, aphasia, and speech disorder.
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Inventors:
CHANG MI SOOK (KR)
KOH SEONG HO (KR)
LEE EUN JI (KR)
KOH SEONG HO (KR)
LEE EUN JI (KR)
Application Number:
PCT/KR2023/006017
Publication Date:
March 07, 2024
Filing Date:
May 03, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV HANYANG IND UNIV COOP FOUND (KR)
UNIV HANYANG IND UNIV COOP FOUND (KR)
International Classes:
A61K35/28; A61K35/30; A61P9/00; A61P9/10; A61P25/00; C12N5/079
Foreign References:
| KR20210023781A | 2021-03-04 | |||
| KR20110104684A | 2011-09-23 |
Other References:
LLORENTE IRENE L., XIE YUAN, MAZZITELLI JOSE A., HATANAKA EMILY A., CINKORNPUMIN JESSICA, MILLER DAVID R., LIN YING, LOWRY WILLIAM: "Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents", SCIENCE TRANSLATIONAL MEDICINE, vol. 13, no. 590, 21 April 2021 (2021-04-21), XP093143843, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aaz6747
SON JEONG-WOO; PARK JIHYE; KIM YE EUN; HA JIEUN; PARK DONG WOO; CHANG MI-SOOK; KOH SEONG-HO: "Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4", MOLECULAR NEUROBIOLOGY, SPRINGER US, NEW YORK, vol. 56, no. 11, 12 May 2019 (2019-05-12), New York, pages 7617 - 7630, XP036919809, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1629-8
STANCIOIU FELICIAN, PAPADAKIS GEORGIOS, LAZOPOULOS GEORGE, SPANDIDOS DEMETRIOS, TSATSAKIS ARISTIDIS, FLOROIU MARIUS, BADIU CORIN: "CD271+ stem cell treatment of patients with chronic stroke", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, 26 June 2020 (2020-06-26), GR , pages 2055 - 2062, XP093143845, ISSN: 1792-0981, DOI: 10.3892/etm.2020.8948
SON JEONG-WOO; PARK JIHYE; KIM YE EUN; HA JIEUN; PARK DONG WOO; CHANG MI-SOOK; KOH SEONG-HO: "Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4", MOLECULAR NEUROBIOLOGY, SPRINGER US, NEW YORK, vol. 56, no. 11, 12 May 2019 (2019-05-12), New York, pages 7617 - 7630, XP036919809, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1629-8
STANCIOIU FELICIAN, PAPADAKIS GEORGIOS, LAZOPOULOS GEORGE, SPANDIDOS DEMETRIOS, TSATSAKIS ARISTIDIS, FLOROIU MARIUS, BADIU CORIN: "CD271+ stem cell treatment of patients with chronic stroke", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, 26 June 2020 (2020-06-26), GR , pages 2055 - 2062, XP093143845, ISSN: 1792-0981, DOI: 10.3892/etm.2020.8948
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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