Title:
PHARMACEUTICAL COMPOSITION USED TO TREAT SUBJECT IN HYPOXIC STATE DUE TO RESPIRATORY FAILURE, ETC.
Document Type and Number:
WIPO Patent Application WO/2021/230317
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition containing oxygen-dissolved perfluorocarbon, for use in administering oxygen to a subject. The present invention also provides a perfluorocarbon-containing pharmaceutical composition, for use in reducing the partial pressure of carbon dioxide in blood.
Inventors:
TAKEBE TAKANORI (JP)
YONEYAMA YOSUKE (JP)
OKABE RYO (JP)
YOSHIKAWA TOYOFUMI (JP)
DATE HIROSHI (JP)
YONEYAMA YOSUKE (JP)
OKABE RYO (JP)
YOSHIKAWA TOYOFUMI (JP)
DATE HIROSHI (JP)
Application Number:
PCT/JP2021/018213
Publication Date:
November 18, 2021
Filing Date:
May 13, 2021
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
International Classes:
A61K31/02; A61K33/00; A61M31/00; A61P7/00; A61P11/00
Foreign References:
| JP2006104179A | 2006-04-20 | |||
| US3975512A | 1976-08-17 |
Other References:
MIIZUTANI KENJI: "Experimental studies on intraluminal administration of oxygenated perflurochemical (PEC) emulsion to the ischemic gastrointestinal tract.", NIPPON SHOKAKIBYO GAKKAI ZASSHI, vol. 83, no. 5, 1 January 1986 (1986-01-01), pages 974 - 983, XP093009617, ISSN: 0446-6586, DOI: 10.11405/nisshoshi1964.83.974
KOTANI KAZUTOSHI, HIDEAKI MORI, HIROSHI DATE, NOBUYOSHI SHIMIZU,: "Transintestinal Oxygenation with Perfluorocarbon Investigation of Perfusion Rate", THE JAPANESE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1 January 2005 (2005-01-01), pages 539 - 544, XP055872859, Retrieved from the Internet [retrieved on 20211214]
RIESS, ARTIFICIAL ORGANS, vol. 8, 1984, pages 44 - 56
MODELL ET AL., FEDERATION PROC, vol. 29, 1970, pages 1731 - 1736
MODELL ET AL., CHEST, vol. 69, 1976, pages 79 - 81
LJ, SLUTSKY AS: "Mechanical Ventilation: State of the Art", MAYO CLIN PROC, vol. 92, 2017, pages 1382 - 400
PATEL BCHATTERJEE SDAVIGNON SHERLIHY JP: "Extracorporeal membrane oxygenation as rescue therapy for severe hypoxemic respiratory failure", J THORAC DIS, vol. 11, 2019, pages S1688 - S97
HENRY BM: "COVID-19, ECMO, and lymphopenia: a word of caution", LANCET RESPIR MED, vol. 8, 2020, pages e24
YANG XYU YXU J ET AL.: "Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study", LANCET RESPIR MED, 2020
NAKAZAWA MSKEITH BSIMON MC: "Oxygen availability and metabolic adaptations.", NAT REV CANCER, vol. 16, 2016, pages 663 - 73
PLAUL SEBARBEITO CGDIAZ AO: "Histochemical differences along the intestine of Corydoras paleatus (Siluriformes: Callichthyidae", REV BIOL TROP, vol. 64, 2016, pages 327 - 40
PARK TJREZNICK JPETERSON BL ET AL.: "Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat", SCIENCE, vol. 356, 2017, pages 307 - 11
HUO DSUN LRU X ET AL.: "Impact of hypoxia stress on the physiological responses of sea cucumber Apostichopus japonicus: respiration, digestion, immunity and oxidative damage", PEERJ, vol. 6, 2018, pages e4651
CARIDI-SCHEIBLE MEBLUM JM: "Use of Perfluorodecalin for Bronchoalveolar Lavage in Case of Severe Pulmonary Hemorrhage and Extracorporeal Membrane Oxygenation: A Case Report and Review of the Literature", A A CASE REP, vol. 7, 2016, pages 215 - 8
FERRARI RSTHOMAZ LSIMONETI LELULBRICH JMANDRADE CF: "Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation", J BRAS PNEUMOL, vol. 45, 2019, pages e20170288
FORGIARINI JUNIOR LAHOLAND ARFORGIARINI LF ET AL.: "Endobronchial perfluorocarbon reduces inflammatory activity before and after lung transplantation in an animal experimental model", MEDIATORS INFLAMM, vol. 2013, 2013, pages 193484
RIESS JG: "Understanding the fundamentals of perfluorocarbons and perfluorocarbon emulsions relevant to in vivo oxygen delivery", ARTIF CELLS BLOOD SUBSTIT IMMOBIL BIOTECHNOL, vol. 33, 2005, pages 47 - 63, XP008112956, DOI: 10.1081/BIO-200046659
YU QLIU KSU LXIA XXU X: "Perfluorocarbon liquid: its application in vitreoretinal surgery and related ocular inflammation", BIOMED RES INT, vol. 2014, 2014, pages 250323
AGUILERA KYBREKKEN RA: "Hypoxia Studies with Pimonidazole in vivo", BIO PROTOC, vol. 4, 2014
LUO WCAO XXU XHUANG SLIU CTOMLJANOVIC T: "Developmental transcriptome analysis and identification of genes involved in formation of intestinal air-breathing function of Dojo loach, Misgurnus anguillicaudatus", SCI REP, vol. 6, 2016, pages 31845
KUZNETSOVA IN: "Stability of perfluorocarbon emulsions and their compatibility with blood serum", ARTIF CELLS BLOOD SUBSTIT IMMOBIL BIOTECHNOL, vol. 26, 1998, pages 181 - 9
HUO DSUN LLI X ET AL.: "Differential Expression of miRNAs in the Respiratory Tree of the Sea Cucumber Apostichopus japonicus Under Hypoxia Stress", G3 (BETHESDA, vol. 7, 2017, pages 3681 - 92
HUANG SCAO XTIAN X: "Transcriptomic Analysis of Compromise Between Air-Breathing and Nutrient Uptake of Posterior Intestine in Loach (Misgurnus anguillicaudatus), an Air-Breathing Fish", MAR BIOTECHNOL (NY, vol. 18, 2016, pages 521 - 33, XP036045528, DOI: 10.1007/s10126-016-9713-9
FISH JECANTU GUTIERREZ MDANG LT ET AL.: "Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network", DEVELOPMENT, vol. 144, 2017, pages 2428 - 44
WANG YNAKAYAMA MPITULESCU ME ET AL.: "Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis", NATURE, vol. 465, 2010, pages 483 - 6, XP037159346, DOI: 10.1038/nature09002
WILSON JMMOREIRA-SILVA JDELGADO IL ET AL.: "Mechanisms of transepithelial ammonia excretion and luminal alkalinization in the gut of an intestinal air-breathing fish, Misgurnus anguilliacaudatus", J EXP BIOL, vol. 216, 2013, pages 623 - 32
CHAMBERS DC, CHERIKH WS, GOLDFARB SB: "The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth adult lung and heart-lung transplant report-2018", FOCUS THEME: MULTIORGAN TRANSPLANTATION. J HEART LUNG TRANSPLANT, vol. 37, 2018, pages 1169 - 83, XP085496839, DOI: 10.1016/j.healun.2018.07.020
KOTANI KAZUTOSHI, HIDEAKI MORI, HIROSHI DATE, NOBUYOSHI SHIMIZU,: "Transintestinal Oxygenation with Perfluorocarbon Investigation of Perfusion Rate", THE JAPANESE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1 January 2005 (2005-01-01), pages 539 - 544, XP055872859, Retrieved from the Internet
RIESS, ARTIFICIAL ORGANS, vol. 8, 1984, pages 44 - 56
MODELL ET AL., FEDERATION PROC, vol. 29, 1970, pages 1731 - 1736
MODELL ET AL., CHEST, vol. 69, 1976, pages 79 - 81
LJ, SLUTSKY AS: "Mechanical Ventilation: State of the Art", MAYO CLIN PROC, vol. 92, 2017, pages 1382 - 400
PATEL BCHATTERJEE SDAVIGNON SHERLIHY JP: "Extracorporeal membrane oxygenation as rescue therapy for severe hypoxemic respiratory failure", J THORAC DIS, vol. 11, 2019, pages S1688 - S97
HENRY BM: "COVID-19, ECMO, and lymphopenia: a word of caution", LANCET RESPIR MED, vol. 8, 2020, pages e24
YANG XYU YXU J ET AL.: "Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study", LANCET RESPIR MED, 2020
NAKAZAWA MSKEITH BSIMON MC: "Oxygen availability and metabolic adaptations.", NAT REV CANCER, vol. 16, 2016, pages 663 - 73
PLAUL SEBARBEITO CGDIAZ AO: "Histochemical differences along the intestine of Corydoras paleatus (Siluriformes: Callichthyidae", REV BIOL TROP, vol. 64, 2016, pages 327 - 40
PARK TJREZNICK JPETERSON BL ET AL.: "Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat", SCIENCE, vol. 356, 2017, pages 307 - 11
HUO DSUN LRU X ET AL.: "Impact of hypoxia stress on the physiological responses of sea cucumber Apostichopus japonicus: respiration, digestion, immunity and oxidative damage", PEERJ, vol. 6, 2018, pages e4651
CARIDI-SCHEIBLE MEBLUM JM: "Use of Perfluorodecalin for Bronchoalveolar Lavage in Case of Severe Pulmonary Hemorrhage and Extracorporeal Membrane Oxygenation: A Case Report and Review of the Literature", A A CASE REP, vol. 7, 2016, pages 215 - 8
FERRARI RSTHOMAZ LSIMONETI LELULBRICH JMANDRADE CF: "Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation", J BRAS PNEUMOL, vol. 45, 2019, pages e20170288
FORGIARINI JUNIOR LAHOLAND ARFORGIARINI LF ET AL.: "Endobronchial perfluorocarbon reduces inflammatory activity before and after lung transplantation in an animal experimental model", MEDIATORS INFLAMM, vol. 2013, 2013, pages 193484
RIESS JG: "Understanding the fundamentals of perfluorocarbons and perfluorocarbon emulsions relevant to in vivo oxygen delivery", ARTIF CELLS BLOOD SUBSTIT IMMOBIL BIOTECHNOL, vol. 33, 2005, pages 47 - 63, XP008112956, DOI: 10.1081/BIO-200046659
YU QLIU KSU LXIA XXU X: "Perfluorocarbon liquid: its application in vitreoretinal surgery and related ocular inflammation", BIOMED RES INT, vol. 2014, 2014, pages 250323
AGUILERA KYBREKKEN RA: "Hypoxia Studies with Pimonidazole in vivo", BIO PROTOC, vol. 4, 2014
LUO WCAO XXU XHUANG SLIU CTOMLJANOVIC T: "Developmental transcriptome analysis and identification of genes involved in formation of intestinal air-breathing function of Dojo loach, Misgurnus anguillicaudatus", SCI REP, vol. 6, 2016, pages 31845
KUZNETSOVA IN: "Stability of perfluorocarbon emulsions and their compatibility with blood serum", ARTIF CELLS BLOOD SUBSTIT IMMOBIL BIOTECHNOL, vol. 26, 1998, pages 181 - 9
HUO DSUN LLI X ET AL.: "Differential Expression of miRNAs in the Respiratory Tree of the Sea Cucumber Apostichopus japonicus Under Hypoxia Stress", G3 (BETHESDA, vol. 7, 2017, pages 3681 - 92
HUANG SCAO XTIAN X: "Transcriptomic Analysis of Compromise Between Air-Breathing and Nutrient Uptake of Posterior Intestine in Loach (Misgurnus anguillicaudatus), an Air-Breathing Fish", MAR BIOTECHNOL (NY, vol. 18, 2016, pages 521 - 33, XP036045528, DOI: 10.1007/s10126-016-9713-9
FISH JECANTU GUTIERREZ MDANG LT ET AL.: "Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network", DEVELOPMENT, vol. 144, 2017, pages 2428 - 44
WANG YNAKAYAMA MPITULESCU ME ET AL.: "Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis", NATURE, vol. 465, 2010, pages 483 - 6, XP037159346, DOI: 10.1038/nature09002
WILSON JMMOREIRA-SILVA JDELGADO IL ET AL.: "Mechanisms of transepithelial ammonia excretion and luminal alkalinization in the gut of an intestinal air-breathing fish, Misgurnus anguilliacaudatus", J EXP BIOL, vol. 216, 2013, pages 623 - 32
CHAMBERS DC, CHERIKH WS, GOLDFARB SB: "The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth adult lung and heart-lung transplant report-2018", FOCUS THEME: MULTIORGAN TRANSPLANTATION. J HEART LUNG TRANSPLANT, vol. 37, 2018, pages 1169 - 83, XP085496839, DOI: 10.1016/j.healun.2018.07.020
Attorney, Agent or Firm:
UMEDA Shinsuke et al. (JP)
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