PHARMACEUTICALLY ACCEPTABLE SALT, CRYSTAL FORM OF AZABICYCLO SUBSTITUTED TRIAZOLE DERIVATIVE AND PREPARATION METHOD

Title:

PHARMACEUTICALLY ACCEPTABLE SALT, CRYSTAL FORM OF AZABICYCLO SUBSTITUTED TRIAZOLE DERIVATIVE AND PREPARATION METHOD

Document Type and Number:

WIPO Patent Application WO/2020/001460

Kind Code:

A1

Abstract:

Provided are a pharmaceutically acceptable salt, a crystal form of an azabicyclo substituted triazole derivative and a preparation method therefor. In particular, provided are a pharmaceutically acceptable salt, a crystal form of a compound 1-(2-chloro-4-fluorophenyl)-3-(5-(methoxymethyl)-4-(6-methoxypyridine-3-yl)-4H-1,2,4-triazol-3-yl)-3-azabicyclo[3.1.0]hexane as shown in formula A, and a preparation method therefor. Relative to free bases, the pharmaceutically acceptable salt of the compound has a higher purity and an even better chemical stability, and is of great significance for developing a drug suitable for industrial production and having a good biological activity. (A)

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Inventors:

WANG LIN (CN)
SHAO QIYUN (CN)
FENG JUN (CN)
HE FENG (CN)
CAO XIAOLI (CN)
DU ZHENXING (CN)

Application Number:

PCT/CN2019/092940

Publication Date:

January 02, 2020

Filing Date:

June 26, 2019

Export Citation:

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Assignee:

JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D401/14; A61K31/4196; A61K31/44; A61P15/00; C07D405/14

Domestic Patent References:

WO2018121551A1	2018-07-05
WO2006092731A1	2006-09-08
WO2006100588A1	2006-09-28
WO2007017752A1	2007-02-15

Foreign References:

CN101107243A

2008-01-16

Other References:

LI, XIN: "Discovery of SHR1653, a Highly Potent and Selective 0 TR Anta- gonist with Improved Blood-Brain Barrier Penetration", ACS MED. CHEM. LETT., vol. 10, no. 6, 29 May 2019 (2019-05-29), pages 996 - 1001, XP055669955

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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