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Title:
PHOSMIDOSINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/011481
Kind Code:
A1
Abstract:
A phosmidosine derivative with excellent stability which is represented by the following general formula (I): (I) (wherein R1 represents C1-8 alkyl; R2 represents hydrogen or a nitrogen-protecting group; R3 and R4 each independently represents hydrogen or a hydroxy-protecting group, provided that R3 and R4 may be bonded to each other to form a ring in cooperation with the two oxygen atoms bonded to these; R5 represents hydrogen or a nitrogen-protecting group; and X represents oxygen or sulfur; provided that when R1 is methyl, then X is not oxygen); or a salt of the derivative.

Inventors:
SEKINE MITSUO (JP)
SEIO KOHJI (JP)
OKADA KAZUHISA (JP)
Application Number:
PCT/JP2003/000985
Publication Date:
February 05, 2004
Filing Date:
January 31, 2003
Export Citation:
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Assignee:
SANKYO CO (JP)
SEKINE MITSUO (JP)
SEIO KOHJI (JP)
OKADA KAZUHISA (JP)
International Classes:
A61K31/708; A61P35/00; A61P43/00; C07F9/572; C07H19/20; (IPC1-7): C07H19/20; A61K31/708; A61P35/00; A61P43/00; C07F9/6561
Domestic Patent References:
WO1996008256A11996-03-21
Foreign References:
JPH093091A1997-01-07
Other References:
SEKINE M. ET AL.: "Total synthesis of agrocin 84 and phosmidosine as naturally occurring nucleotidic antibiotics having P-N bond linkages", J. SYNTH. ORG. CHEM., JPN, vol. 59, no. 11, 2001, pages 1109 - 1120, XP002965224
MORIGUCHI T. ET AL.: "First synthesis and anticancer activity of phosmidosine and its related compounds", J. ORG. CHEM., vol. 67, no. 10, 2002, pages 3290 - 3300, XP002965225
Attorney, Agent or Firm:
SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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