Title:
PIPERIDINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF TACHYKININS
Document Type and Number:
WIPO Patent Application WO2003066621
Kind Code:
A8
Abstract:
The present invention relates to piperidine derivatives of formula (I); wherein R represents halogen or C 1-4 alkyl; R1 represents hydrogen or C1-4 alkyl; R2 represents hydrogen, C1-4 alkyl; R3 represents hydrogen, C1-4 alkyl;R4 represents trifluoromethyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy or halogen; R5 represents hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C(O)R6 or S(O)2R6;R6 represents C 1-4 alkyl or C3-7 cycloalkyl; m is zero or an integer from 1 to 3; n is an integer from 1 to 3; p is an integer from 1 to 2; X and Y are independently C(O) or CH2; provided that i) X and Y are not both C(O) and ii) when X and Y are both CH2 and p is 1, R5 is not hydrogen, C1-4 alkyl or C(O)R6 ; and pharmaceutically acceptable salts and solvates thereof, the process for their preparation and their use in the treatment of condition mediated by tachykinins.
Inventors:
ALVARO GIUSEPPE (IT)
DI FABIO ROMANO (IT)
DI FABIO ROMANO (IT)
Application Number:
PCT/GB2003/000501
Publication Date:
November 13, 2003
Filing Date:
February 05, 2003
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
ALVARO GIUSEPPE (IT)
DI FABIO ROMANO (IT)
ALVARO GIUSEPPE (IT)
DI FABIO ROMANO (IT)
International Classes:
A61K31/496; A61P1/04; A61P1/08; A61P1/14; A61P3/10; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P11/14; A61P13/02; A61P13/10; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P27/16; A61P29/00; A61P31/16; A61P31/22; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D401/04; (IPC1-7): C07D401/04; A61K31/496; A61P25/00
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