Title:
PLATELET BIOMARKERS FOR THE DETECTION OF DISEASE
Document Type and Number:
WIPO Patent Application WO2005103281
Kind Code:
A3
Abstract:
The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other angiogenic diseases or disorders can be predicted.
Inventors:
FOLKMAN JUDAH (US)
KLEMENT GIANNOULA (US)
KLEMENT GIANNOULA (US)
Application Number:
PCT/US2005/014210
Publication Date:
April 06, 2006
Filing Date:
April 26, 2005
Export Citation:
Assignee:
CHILDRENS MEDICAL CENTER (US)
FOLKMAN JUDAH (US)
KLEMENT GIANNOULA (US)
FOLKMAN JUDAH (US)
KLEMENT GIANNOULA (US)
International Classes:
C12Q1/00; G01N33/574; G01N33/68; G01N33/86
Foreign References:
| US5776704A | 1998-07-07 |
Other References:
CLAFFEY K.P. ET AL: "Molecular Profiling of Angiogenic Markers", AMERICAN JOURNAL OF PATHOLOGY, vol. 161, no. 1, July 2002 (2002-07-01), pages 7 - 11, XP002995366
NADAR S.K. ET AL: "Plasma and platelet-derived vascular endothelial growth factor and angiopoietin-1 in hypertension: effects of antihypertensive therapy", JOURNAL OF INTERNAL MEDICINE, vol. 256, 2004, pages 331 - 337, XP002995367
CAINE G.J. ET AL: "Platelet-derived VEGF, Flt-1, Angiopoietin-1 and P-selectin in breast and prostate cancer: further evidence for a role of platelets in tumour angiogenesis", ANNALS OF MEDICINE, vol. 36, 2004, pages 273 - 277, XP008061172
SALGADO R. ET AL: "Platelets and vascular endothelial growth factor (VEGF): A morphological and functional study", ANGIOGENESIS, vol. 4, 2001, pages 37 - 43, XP002995368
NADAR S.K. ET AL: "Plasma and platelet-derived vascular endothelial growth factor and angiopoietin-1 in hypertension: effects of antihypertensive therapy", JOURNAL OF INTERNAL MEDICINE, vol. 256, 2004, pages 331 - 337, XP002995367
CAINE G.J. ET AL: "Platelet-derived VEGF, Flt-1, Angiopoietin-1 and P-selectin in breast and prostate cancer: further evidence for a role of platelets in tumour angiogenesis", ANNALS OF MEDICINE, vol. 36, 2004, pages 273 - 277, XP008061172
SALGADO R. ET AL: "Platelets and vascular endothelial growth factor (VEGF): A morphological and functional study", ANGIOGENESIS, vol. 4, 2001, pages 37 - 43, XP002995368
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