PLATINUM COMPLEXES AND METHODS OF USE THEREOF

WIPO Patent Application WO/2018/024172

A1

Disclosed herein are platinum(II) complexes that can include complexes of the formula, or pharmaceutically acceptable salts thereof, wherein: R1 and R2 are independently selected from the group consisting of an amine, an optionally substituted amine, and an optionally substituted heterocyclic amine; or the pair of R1 and R2 are joined together to form a bidentate ligand containing nitrogen atoms; R3 is selected from the group consisting of H, alkyl optionally substituted, aryl optionally substituted, thienyl optionally substituted, and polyethylene glycol; R4, R5, R6, and R7 are independently selected from the group consisting of H, halide, -OR, alkyl optionally substituted and polyethylene glycol, or each pair of R4 and R5, R5 and R6, R6 and R7 is joined together to form Y is selected from a group consisting of a sulfur atom, oxygen atom, and NR (wherein R is selected from the group consisting of H and alkyl optionally substituted); Z is selected from a group consisting of a carbon atom and a nitrogen atom; and X is selected from a group consisting of fluoride, chloride, bromide, iodide, trifluoromethanesulfonate, acetate, nitrate, perchlorate, hexafluorophosphate, sulfate and phosphate. Also disclosed are methods for using the platinum (II) complexes in the treatment of cancer and in the visualization inside cells.

CHE CHI MING (CN)
HU DI (CN)
CHAN LAI FUNG (CN)

PCT/CN2017/095150

February 08, 2018

July 31, 2017

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UNIV HONG KONG (CN)

C07F15/00

WO2010087976A2	2010-08-05
WO2014165782A2	2014-10-09

CN1680384A	2005-10-12
CN1197798A	1998-11-04

CHINA PATENT AGENT (H.K.) LTD. (CN)

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