Title:
PLATINUM SULFIDE PROTEIN NANOPARTICLE HAVING NEAR-INFRARED PHOTOTHERMAL EFFECT AND MULTI-MODAL IMAGING FUNCTION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/029098
Kind Code:
A1
Abstract:
A platinum sulfide protein nanoparticle having near-infrared photothermal effect and multi-modal imaging function, a preparation method therefor and an application thereof. The platinum sulfide nanoparticle having near-infrared photothermal effect and multi-modal imaging function is prepared in aqueous phase by means of formulation screening and process limitation. The nanoparticle has an ultra-small particle size and good stability as well as tumor targeting and photothermal effects and integrates functions of near-infrared imaging, CT imaging, and thermal imaging, so as to achieve high sensitivity, high resolution, and precise positioning of tumors, and to produce high-efficiency photothermal effects under the excitation of near-infrared light to kill tumor cells by thermal ablation, thereby achieving the purpose of efficient, safe, visual, and accurate treatment of tumors. The nanoparticle has the potential for further development and clinical application.
Inventors:
YANG HONG (CN)
CHEN HUABING (CN)
WANG XUE (CN)
KE HENGTE (CN)
LI MING (CN)
XU TAO (CN)
ZHANG MIYA (CN)
CHEN HUABING (CN)
WANG XUE (CN)
KE HENGTE (CN)
LI MING (CN)
XU TAO (CN)
ZHANG MIYA (CN)
Application Number:
PCT/CN2018/099268
Publication Date:
February 13, 2020
Filing Date:
August 07, 2018
Export Citation:
Assignee:
ZHANGJIAGANG INST IND TECH SOOCHOW UNIV (CN)
UNIV SOOCHOW (CN)
UNIV SOOCHOW (CN)
International Classes:
A61K49/00; A61K41/00; A61K49/04; A61K49/22; A61P35/00
Foreign References:
| CN107551279A | 2018-01-09 | |||
| CN105106958A | 2015-12-02 | |||
| CN105056233A | 2015-11-18 | |||
| CN106267198A | 2017-01-04 | |||
| CN104587493A | 2015-05-06 |
Other References:
TANG, Y. ET AL.: "Albumin-Coordinated Assembly of Clearable Platinum Nanodots for Photo- Induced Cancer Theranostics", BIOMATERIALS, vol. 154, 20 October 2017 (2017-10-20), pages 248 - 260, XP055682636
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
Download PDF: